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| 32 | <o:Author>incerti</o:Author>
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| 33 | <o:LastAuthor>Sébastien Incerti</o:LastAuthor>
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| 170 | <div class=Section1>
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| 171 |
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| 172 | <p class=MsoNormal align=center style='text-align:center'><b><span lang=EN-GB
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| 173 | style='font-size:20.0pt;font-family:Arial;color:#00CCFF;mso-ansi-language:EN-GB'>Geant4
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| 174 | <span class=SpellE>Microbeam</span> Advanced Example<o:p></o:p></span></b></p>
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| 175 |
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| 176 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph'><span
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| 177 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p>
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| 178 |
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| 179 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph'><span
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| 180 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p>
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| 181 |
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| 182 | <p class=MsoNormal align=center style='text-align:center'><b><span lang=EN-GB
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| 183 | style='font-family:Arial;color:#FFCC99;mso-ansi-language:EN-GB'>Interface
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| 184 | Physics Biology group<o:p></o:p></span></b></p>
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| 185 |
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| 186 | <p class=MsoNormal align=center style='text-align:center'><span class=GramE><span
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| 187 | style='font-family:Arial;color:#FFCC99'>( <b>S</b></span></span><b><span
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| 188 | style='font-family:Arial;color:#FFCC99'>. Incerti</span></b><span
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| 189 | style='font-family:Arial;color:#FFCC99'>*, O. <span class=SpellE>Boissonnade</span>,
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| 190 | C. <span class=SpellE>Habchi</span>, <span class=SpellE>Ph</span>. <span
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| 191 | class=SpellE>Moretto</span>, D. T. <span class=SpellE>Nguyen</span>, T. <span
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| 192 | class=SpellE>Pouthier</span>, H. <span class=SpellE>Seznec</span>, Q. Zhang )<o:p></o:p></span></p>
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| 193 |
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| 194 | <p class=MsoNormal align=center style='text-align:center;mso-layout-grid-align:
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| 195 | none;text-autospace:none'><span style='font-family:Arial;color:#FFCC99'><o:p> </o:p></span></p>
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| 196 |
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| 197 | <p class=MsoNormal align=center style='text-align:center;mso-layout-grid-align:
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| 198 | none;text-autospace:none'><b><span style='font-family:Arial;color:#FFCC99'>Centre
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| 199 | dEtudes Nucléaires de <span class=SpellE>Bordeaux-Gradignan</span> (CENBG)<o:p></o:p></span></b></p>
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| 200 |
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| 201 | <p class=MsoNormal align=center style='text-align:center;mso-layout-grid-align:
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| 202 | none;text-autospace:none'><b><span lang=EN-GB style='font-family:Arial;
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| 203 | color:#FFCC99;mso-ansi-language:EN-GB'>IN2P3 / CNRS / </span></b><st1:City><st1:place><b><span
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| 204 | lang=EN-GB style='font-family:Arial;color:#FFCC99;mso-ansi-language:EN-GB'>Bordeaux</span></b></st1:place></st1:City><b><span
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| 205 | lang=EN-GB style='font-family:Arial;color:#FFCC99;mso-ansi-language:EN-GB'> 1
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| 206 | University<o:p></o:p></span></b></p>
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| 207 |
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| 208 | <p class=MsoNormal align=center style='text-align:center;mso-layout-grid-align:
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| 209 | none;text-autospace:none'><b><span lang=EN-GB style='font-family:Arial;
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| 210 | color:#FFCC99;mso-ansi-language:EN-GB'>33175 <span class=SpellE>Gradignan</span><o:p></o:p></span></b></p>
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| 211 |
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| 212 | <p class=MsoNormal align=center style='text-align:center;mso-layout-grid-align:
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| 213 | none;text-autospace:none'><st1:country-region><st1:place><b><span lang=EN-GB
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| 214 | style='font-family:Arial;color:#FFCC99;mso-ansi-language:EN-GB'>France</span></b></st1:place></st1:country-region><b><span
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| 215 | lang=EN-GB style='font-family:Arial;color:#FFCC99;mso-ansi-language:EN-GB'><o:p></o:p></span></b></p>
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| 216 |
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| 217 | <p class=MsoNormal align=center style='text-align:center;mso-layout-grid-align:
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| 218 | none;text-autospace:none'><span lang=EN-GB style='font-family:Arial;color:#FFCC99;
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| 219 | mso-ansi-language:EN-GB'><o:p> </o:p></span></p>
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| 220 |
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| 221 | <p class=MsoNormal align=center style='text-align:center;mso-layout-grid-align:
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| 222 | none;text-autospace:none'><span lang=EN-GB style='font-family:Arial;color:#FFCC99;
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| 223 | mso-ansi-language:EN-GB'>* <span class=GramE>corresponding</span> author e-mail
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| 224 | : </span><span style='font-family:Arial;color:aqua'><a
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| 225 | href="mailto:incerti@cenbg.in2p3.fr"><span lang=EN-GB style='color:aqua;
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| 226 | mso-ansi-language:EN-GB;text-decoration:none;text-underline:none'>incerti@cenbg.in2p3.fr</span></a></span><span
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| 227 | style='font-family:Arial;color:aqua;mso-ansi-language:EN-GB'> <span lang=EN-GB><o:p></o:p></span></span></p>
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| 228 |
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| 229 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
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| 230 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB
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| 231 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p>
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| 232 |
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| 233 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
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| 234 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB
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| 235 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><span
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| 236 | style='mso-spacerun:yes'>
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| 237 | </span><o:p></o:p></span></p>
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| 238 |
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| 239 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
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| 240 | mso-layout-grid-align:none;text-autospace:none'><b><span lang=EN-GB
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| 241 | style='font-family:Arial;color:#66CCFF;mso-ansi-language:EN-GB'>INTRODUCTION<o:p></o:p></span></b></p>
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| 242 |
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| 243 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
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| 244 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB
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| 245 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p>
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| 246 |
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| 247 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
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| 248 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB
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| 249 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>The <span
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| 250 | class=SpellE>microbeam</span> example simulates the <span class=SpellE>microbeam</span>
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| 251 | cellular irradiation beam line installed on the AIFIRA electrostatic
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| 252 | accelerator facility located at CENBG, </span><st1:place><st1:City><span
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| 253 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>Bordeaux-<span
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| 254 | class=SpellE>Gradignan</span></span></st1:City><span lang=EN-GB
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| 255 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>, </span><st1:country-region><span
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| 256 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>France</span></st1:country-region></st1:place><span
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| 257 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>. This
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| 258 | setup is mainly used to investigate the effects of low dose irradiation on
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| 259 | living cells. The <span class=SpellE>microbeam</span> line allows </span><b><span
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| 260 | lang=EN-GB style='font-family:Arial;color:yellow;mso-ansi-language:EN-GB'>irradiation
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| 261 | of</span></b><span lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:
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| 262 | EN-GB'> </span><b><span lang=EN-GB style='font-family:Arial;color:yellow;
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| 263 | mso-ansi-language:EN-GB'>individual biological living cells</span></b><span
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| 264 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'> in
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| 265 | culture medium in single ion mode, with an </span><b><span lang=EN-GB
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| 266 | style='font-family:Arial;color:yellow;mso-ansi-language:EN-GB'>exact control of
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| 267 | the delivered dose to a particular cell</span></b><span lang=EN-GB
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| 268 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'> among the cell
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| 269 | population. This Geant4 example simulates the <span class=SpellE>microbeam</span>
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| 270 | line in a configuration of irradiation with 3 MeV incident alpha particles and
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| 271 | allows the calculation of the dose deposited by the incident particles in the
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| 272 | cell cytoplasm and in the cell nucleus, which are inaccessible by experimental
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| 273 | measurements. For the first time in </span><st1:place><span lang=EN-GB
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| 274 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>Monte Carlo</span></st1:place><span
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| 275 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'> <span
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| 276 | class=SpellE>microdosimetry</span>, the simulation includes a realistic cell
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| 277 | phantom obtained from <span class=SpellE>confocal</span> microscopy. <o:p></o:p></span></p>
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| 278 |
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| 279 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
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| 280 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB
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| 281 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p>
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| 282 |
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| 283 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
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| 284 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB
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| 285 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>For more
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| 286 | information on this irradiation facility, please <span class=GramE>visit :</span><o:p></o:p></span></p>
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| 287 |
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| 288 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
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| 289 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB
|
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| 290 | style='font-family:Arial;color:aqua;mso-ansi-language:EN-GB'><o:p> </o:p></span></p>
|
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| 291 |
|
|---|
| 292 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm;
|
|---|
| 293 | mso-layout-grid-align:none;text-autospace:none'><b><span lang=EN-GB
|
|---|
| 294 | style='font-family:Arial;color:aqua;mso-ansi-language:EN-GB'><a
|
|---|
| 295 | href="http://www.cenbg.in2p3.fr/"><span style='color:aqua;text-decoration:none;
|
|---|
| 296 | text-underline:none'>http://www.cenbg.in2p3.fr</span></a><o:p></o:p></span></b></p>
|
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| 297 |
|
|---|
| 298 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm;
|
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| 299 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB
|
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| 300 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p>
|
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| 301 |
|
|---|
| 302 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm;
|
|---|
| 303 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB
|
|---|
| 304 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p>
|
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| 305 |
|
|---|
| 306 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm;
|
|---|
| 307 | mso-layout-grid-align:none;text-autospace:none'><span style='font-family:Arial;
|
|---|
| 308 | color:white'><!--[if gte vml 1]><v:shapetype id="_x0000_t75" coordsize="21600,21600"
|
|---|
| 309 | o:spt="75" o:preferrelative="t" path="m@4@5l@4@11@9@11@9@5xe" filled="f"
|
|---|
| 310 | stroked="f">
|
|---|
| 311 | <v:stroke joinstyle="miter"/>
|
|---|
| 312 | <v:formulas>
|
|---|
| 313 | <v:f eqn="if lineDrawn pixelLineWidth 0"/>
|
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| 314 | <v:f eqn="sum @0 1 0"/>
|
|---|
| 315 | <v:f eqn="sum 0 0 @1"/>
|
|---|
| 316 | <v:f eqn="prod @2 1 2"/>
|
|---|
| 317 | <v:f eqn="prod @3 21600 pixelWidth"/>
|
|---|
| 318 | <v:f eqn="prod @3 21600 pixelHeight"/>
|
|---|
| 319 | <v:f eqn="sum @0 0 1"/>
|
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| 320 | <v:f eqn="prod @6 1 2"/>
|
|---|
| 321 | <v:f eqn="prod @7 21600 pixelWidth"/>
|
|---|
| 322 | <v:f eqn="sum @8 21600 0"/>
|
|---|
| 323 | <v:f eqn="prod @7 21600 pixelHeight"/>
|
|---|
| 324 | <v:f eqn="sum @10 21600 0"/>
|
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| 325 | </v:formulas>
|
|---|
| 326 | <v:path o:extrusionok="f" gradientshapeok="t" o:connecttype="rect"/>
|
|---|
| 327 | <o:lock v:ext="edit" aspectratio="t"/>
|
|---|
| 328 | </v:shapetype><v:shape id="_x0000_i1025" type="#_x0000_t75" style='width:408.75pt;
|
|---|
| 329 | height:279pt;mso-position-vertical:absolute' o:ole="" o:allowoverlap="f"
|
|---|
| 330 | fillcolor="#6cf">
|
|---|
| 331 | <v:imagedata src="microbeam_fichiers/image001.png" o:title="" croptop="1077f"
|
|---|
| 332 | cropright="1886f"/>
|
|---|
| 333 | </v:shape><![endif]--><![if !vml]><img border=0 width=545 height=372
|
|---|
| 334 | src="microbeam_fichiers/image002.gif" v:shapes="_x0000_i1025"><![endif]><!--[if gte mso 9]><xml>
|
|---|
| 335 | <o:OLEObject Type="Embed" ProgID="MSPhotoEd.3" ShapeID="_x0000_i1025"
|
|---|
| 336 | DrawAspect="Content" ObjectID="_1234075214">
|
|---|
| 337 | </o:OLEObject>
|
|---|
| 338 | </xml><![endif]--><o:p></o:p></span></p>
|
|---|
| 339 |
|
|---|
| 340 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm;
|
|---|
| 341 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB
|
|---|
| 342 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p>
|
|---|
| 343 |
|
|---|
| 344 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm;
|
|---|
| 345 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB
|
|---|
| 346 | style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'>Schematic view
|
|---|
| 347 | of the CENBG five AIFIRA beam <span class=GramE>lines :</span> <br>
|
|---|
| 348 | the <span class=SpellE>microbeam</span> line is located at 10° from the main
|
|---|
| 349 | exit of the switching magnet (© CENBG)<o:p></o:p></span></p>
|
|---|
| 350 |
|
|---|
| 351 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm;
|
|---|
| 352 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB
|
|---|
| 353 | style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'><o:p> </o:p></span></p>
|
|---|
| 354 |
|
|---|
| 355 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm;
|
|---|
| 356 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB
|
|---|
| 357 | style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'><o:p> </o:p></span></p>
|
|---|
| 358 |
|
|---|
| 359 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm;
|
|---|
| 360 | mso-layout-grid-align:none;text-autospace:none'><!--[if gte vml 1]><v:shape
|
|---|
| 361 | id="_x0000_i1026" type="#_x0000_t75" style='width:274.5pt;height:418.5pt'>
|
|---|
| 362 | <v:imagedata src="microbeam_fichiers/image003.png" o:title=""/>
|
|---|
| 363 | </v:shape><![endif]--><![if !vml]><img border=0 width=366 height=558
|
|---|
| 364 | src="microbeam_fichiers/image004.jpg" v:shapes="_x0000_i1026"><![endif]></p>
|
|---|
| 365 |
|
|---|
| 366 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm;
|
|---|
| 367 | mso-layout-grid-align:none;text-autospace:none'><o:p> </o:p></p>
|
|---|
| 368 |
|
|---|
| 369 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm;
|
|---|
| 370 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB
|
|---|
| 371 | style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'>View of the
|
|---|
| 372 | CENBG <span class=SpellE>microbeam</span> line (© CENBG)</span><span
|
|---|
| 373 | lang=EN-GB style='mso-ansi-language:EN-GB'><o:p></o:p></span></p>
|
|---|
| 374 |
|
|---|
| 375 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 376 | tab-stops:right 16.0cm;mso-layout-grid-align:none;text-autospace:none'><span
|
|---|
| 377 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p>
|
|---|
| 378 |
|
|---|
| 379 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 380 | tab-stops:right 16.0cm;mso-layout-grid-align:none;text-autospace:none'><span
|
|---|
| 381 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p>
|
|---|
| 382 |
|
|---|
| 383 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 384 | mso-layout-grid-align:none;text-autospace:none'><b><span lang=EN-GB
|
|---|
| 385 | style='font-family:Arial;color:#66CCFF;mso-ansi-language:EN-GB'>SIMULATED SETUP<o:p></o:p></span></b></p>
|
|---|
| 386 |
|
|---|
| 387 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 388 | tab-stops:right 16.0cm;mso-layout-grid-align:none;text-autospace:none'><span
|
|---|
| 389 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p>
|
|---|
| 390 |
|
|---|
| 391 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 392 | tab-stops:right 16.0cm;mso-layout-grid-align:none;text-autospace:none'><span
|
|---|
| 393 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>The beam
|
|---|
| 394 | is emitted just before the 10° switching magnet taking into account
|
|---|
| 395 | experimental beam parameters <span class=GramE>measurements ;</span> the main
|
|---|
| 396 | elements simulated are :<o:p></o:p></span></p>
|
|---|
| 397 |
|
|---|
| 398 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 399 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB
|
|---|
| 400 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p>
|
|---|
| 401 |
|
|---|
| 402 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 403 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB
|
|---|
| 404 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>1. A </span><b><span
|
|---|
| 405 | lang=EN-GB style='font-family:Arial;color:yellow;mso-ansi-language:EN-GB'>switching
|
|---|
| 406 | dipole magnet</span></b><span lang=EN-GB style='font-family:Arial;color:white;
|
|---|
| 407 | mso-ansi-language:EN-GB'> with fringing field, to deflect by 10° the 3 MeV
|
|---|
| 408 | alpha beam generated by the electrostatic accelerator into the <span
|
|---|
| 409 | class=SpellE>microbeam</span> line, oriented at 10 degrees from the main beam
|
|---|
| 410 | direction;<o:p></o:p></span></p>
|
|---|
| 411 |
|
|---|
| 412 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 413 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB
|
|---|
| 414 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p>
|
|---|
| 415 |
|
|---|
| 416 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 417 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB
|
|---|
| 418 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>2. A </span><b><span
|
|---|
| 419 | lang=EN-GB style='font-family:Arial;color:yellow;mso-ansi-language:EN-GB'>circular
|
|---|
| 420 | object collimator</span></b><span lang=EN-GB style='font-family:Arial;
|
|---|
| 421 | color:white;mso-ansi-language:EN-GB'>, defining the incident beam size at the <span
|
|---|
| 422 | class=SpellE>microbeam</span> line entrance; the collimator has been simulated
|
|---|
| 423 | from realistic electron microscopy images;<o:p></o:p></span></p>
|
|---|
| 424 |
|
|---|
| 425 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 426 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB
|
|---|
| 427 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p>
|
|---|
| 428 |
|
|---|
| 429 | <p class=MsoNormal align=center style='text-align:center;mso-layout-grid-align:
|
|---|
| 430 | none;text-autospace:none'><!--[if gte vml 1]><v:shape id="_x0000_i1027" type="#_x0000_t75"
|
|---|
| 431 | style='width:182.25pt;height:200.25pt;mso-position-horizontal:absolute;
|
|---|
| 432 | mso-position-horizontal-relative:text;mso-position-vertical:absolute;
|
|---|
| 433 | mso-position-vertical-relative:text' o:allowoverlap="f">
|
|---|
| 434 | <v:imagedata src="microbeam_fichiers/image015.emz" o:title=""/>
|
|---|
| 435 | </v:shape><![endif]--><![if !vml]><img border=0 width=243 height=267
|
|---|
| 436 | src="microbeam_fichiers/image006.gif" v:shapes="_x0000_i1027"><![endif]></p>
|
|---|
| 437 |
|
|---|
| 438 | <p class=MsoNormal align=center style='text-align:center;mso-layout-grid-align:
|
|---|
| 439 | none;text-autospace:none'><o:p> </o:p></p>
|
|---|
| 440 |
|
|---|
| 441 | <p class=MsoNormal align=center style='text-align:center;mso-layout-grid-align:
|
|---|
| 442 | none;text-autospace:none'><span lang=EN-GB style='font-family:Arial;color:#CCFFCC;
|
|---|
| 443 | mso-ansi-language:EN-GB'>Collimator geometry implemented in Geant4 as embedded
|
|---|
| 444 | cones </span><span lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:
|
|---|
| 445 | EN-GB'><o:p></o:p></span></p>
|
|---|
| 446 |
|
|---|
| 447 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 448 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB
|
|---|
| 449 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p>
|
|---|
| 450 |
|
|---|
| 451 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 452 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB
|
|---|
| 453 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p>
|
|---|
| 454 |
|
|---|
| 455 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 456 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB
|
|---|
| 457 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>3. A </span><b><span
|
|---|
| 458 | lang=EN-GB style='font-family:Arial;color:yellow;mso-ansi-language:EN-GB'>quadrupole
|
|---|
| 459 | based magnetic symmetric focusing system</span></b><span lang=EN-GB
|
|---|
| 460 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'> allowing equal
|
|---|
| 461 | transverse demagnifications of 10. Fringe fields are calculated from Enges
|
|---|
| 462 | model.<o:p></o:p></span></p>
|
|---|
| 463 |
|
|---|
| 464 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 465 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB
|
|---|
| 466 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p>
|
|---|
| 467 |
|
|---|
| 468 | <p class=MsoNormal align=center style='text-align:center;mso-layout-grid-align:
|
|---|
| 469 | none;text-autospace:none'><span lang=EN-GB style='font-family:Arial;color:white;
|
|---|
| 470 | mso-ansi-language:EN-GB'><!--[if gte vml 1]><v:shape id="_x0000_i1028" type="#_x0000_t75"
|
|---|
| 471 | style='width:457.5pt;height:235.5pt'>
|
|---|
| 472 | <v:imagedata src="microbeam_fichiers/image007.jpg" o:title="beam" cropleft="1038f"
|
|---|
| 473 | chromakey="white" gain="45875f" blacklevel=".5" grayscale="t" bilevel="t"/>
|
|---|
| 474 | </v:shape><![endif]--><![if !vml]><img border=0 width=610 height=314
|
|---|
| 475 | src="microbeam_fichiers/image008.gif" v:shapes="_x0000_i1028"><![endif]><o:p></o:p></span></p>
|
|---|
| 476 |
|
|---|
| 477 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm;
|
|---|
| 478 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB
|
|---|
| 479 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p>
|
|---|
| 480 |
|
|---|
| 481 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm;
|
|---|
| 482 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB
|
|---|
| 483 | style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'>Geant4 fine
|
|---|
| 484 | ray-tracing of beam profile inside the focusing quadruplet in both horizontal
|
|---|
| 485 | and transverse planes, showing the beam focus point.<o:p></o:p></span></p>
|
|---|
| 486 |
|
|---|
| 487 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm;
|
|---|
| 488 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB
|
|---|
| 489 | style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'><o:p> </o:p></span></p>
|
|---|
| 490 |
|
|---|
| 491 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 492 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB
|
|---|
| 493 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p>
|
|---|
| 494 |
|
|---|
| 495 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 496 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB
|
|---|
| 497 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>4. A dedicated </span><b><span
|
|---|
| 498 | lang=EN-GB style='font-family:Arial;color:yellow;mso-ansi-language:EN-GB'>cellular
|
|---|
| 499 | irradiation chamber setup</span></b><span lang=EN-GB style='font-family:Arial;
|
|---|
| 500 | color:white;mso-ansi-language:EN-GB'>, taking into account all the elements
|
|---|
| 501 | encountered by the incident beam (diaphragm, gas detector, <span class=SpellE>isobutane</span>,
|
|---|
| 502 | beam extraction window, air, culture foil, culture medium, cell dish
|
|---|
| 503 | ) ;<o:p></o:p></span></p>
|
|---|
| 504 |
|
|---|
| 505 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 506 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB
|
|---|
| 507 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p>
|
|---|
| 508 |
|
|---|
| 509 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 510 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB
|
|---|
| 511 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>5. A set of
|
|---|
| 512 | horizontal and vertical </span><b><span lang=EN-GB style='font-family:Arial;
|
|---|
| 513 | color:yellow;mso-ansi-language:EN-GB'>electrostatic deflecting plates</span></b><span
|
|---|
| 514 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'> which
|
|---|
| 515 | can be turned on or off to deflect the beam on target; <o:p></o:p></span></p>
|
|---|
| 516 |
|
|---|
| 517 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 518 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB
|
|---|
| 519 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p>
|
|---|
| 520 |
|
|---|
| 521 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 522 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB
|
|---|
| 523 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>6. A </span><b><span
|
|---|
| 524 | lang=EN-GB style='font-family:Arial;color:yellow;mso-ansi-language:EN-GB'>realistic
|
|---|
| 525 | human <span class=SpellE>keratinocyte</span> <span class=SpellE>voxellized</span>
|
|---|
| 526 | cell</span></b><span lang=EN-GB style='font-family:Arial;color:white;
|
|---|
| 527 | mso-ansi-language:EN-GB'> observed from confocal microscopy and taking into
|
|---|
| 528 | account realistic nucleus and cytoplasm chemical compositions. The phantom uses
|
|---|
| 529 | the G4PVParameterised class.<o:p></o:p></span></p>
|
|---|
| 530 |
|
|---|
| 531 | <p class=MsoNormal align=center style='text-align:center;mso-layout-grid-align:
|
|---|
| 532 | none;text-autospace:none'><span lang=EN-GB style='mso-ansi-language:EN-GB'><o:p> </o:p></span></p>
|
|---|
| 533 |
|
|---|
| 534 | <p class=MsoNormal align=center style='text-align:center;mso-layout-grid-align:
|
|---|
| 535 | none;text-autospace:none'><span lang=EN-GB style='mso-ansi-language:EN-GB'><o:p> </o:p></span></p>
|
|---|
| 536 |
|
|---|
| 537 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm;
|
|---|
| 538 | mso-layout-grid-align:none;text-autospace:none'><!--[if gte vml 1]><v:shape
|
|---|
| 539 | id="_x0000_i1029" type="#_x0000_t75" style='width:195.75pt;height:267.75pt'>
|
|---|
| 540 | <v:imagedata src="microbeam_fichiers/image009.jpg" o:title="24h" croptop="10627f"
|
|---|
| 541 | cropbottom="7872f" cropleft="14295f" cropright="12755f"/>
|
|---|
| 542 | </v:shape><![endif]--><![if !vml]><img border=0 width=261 height=357
|
|---|
| 543 | src="microbeam_fichiers/image010.jpg" v:shapes="_x0000_i1029"><![endif]><span
|
|---|
| 544 | lang=EN-GB style='mso-ansi-language:EN-GB'><o:p></o:p></span></p>
|
|---|
| 545 |
|
|---|
| 546 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm;
|
|---|
| 547 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB
|
|---|
| 548 | style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'><o:p> </o:p></span></p>
|
|---|
| 549 |
|
|---|
| 550 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm;
|
|---|
| 551 | mso-layout-grid-align:none;text-autospace:none'><span class=SpellE><span
|
|---|
| 552 | lang=EN-GB style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'>Confocal</span></span><span
|
|---|
| 553 | lang=EN-GB style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'>
|
|---|
| 554 | microscopy image of a HaCat cell showing the cytoplasm (red) and the nucleus
|
|---|
| 555 | (purple) <br>
|
|---|
| 556 | © CENBG<o:p></o:p></span></p>
|
|---|
| 557 |
|
|---|
| 558 | <p class=MsoNormal align=center style='text-align:center;mso-layout-grid-align:
|
|---|
| 559 | none;text-autospace:none'><span lang=EN-GB style='mso-ansi-language:EN-GB'><o:p> </o:p></span></p>
|
|---|
| 560 |
|
|---|
| 561 | <p class=MsoNormal align=center style='text-align:center;mso-layout-grid-align:
|
|---|
| 562 | none;text-autospace:none'><span lang=EN-GB style='mso-ansi-language:EN-GB'><span
|
|---|
| 563 | style='mso-tab-count:2'> </span></span><!--[if gte vml 1]><v:shape
|
|---|
| 564 | id="_x0000_i1030" type="#_x0000_t75" style='width:323.25pt;height:321.75pt'>
|
|---|
| 565 | <v:imagedata src="microbeam_fichiers/image011.png" o:title=""/>
|
|---|
| 566 | </v:shape><![endif]--><![if !vml]><img border=0 width=431 height=429
|
|---|
| 567 | src="microbeam_fichiers/image012.jpg" v:shapes="_x0000_i1030"><![endif]><span
|
|---|
| 568 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p></o:p></span></p>
|
|---|
| 569 |
|
|---|
| 570 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 571 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB
|
|---|
| 572 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p>
|
|---|
| 573 |
|
|---|
| 574 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm;
|
|---|
| 575 | mso-layout-grid-align:none;text-autospace:none'><span class=GramE><span
|
|---|
| 576 | lang=EN-GB style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'>Corresponding
|
|---|
| 577 | Geant4 phantom showing four incident alpha particles penetrating the cell.</span></span><span
|
|---|
| 578 | lang=EN-GB style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'> <br>
|
|---|
| 579 | The phantom is made of voxels with a size of 489 nm (X) x 489 nm (Y) x 163 nm
|
|---|
| 580 | (Z). <br>
|
|---|
| 581 | Approximately 4x10<sup>4</sup> <span class=SpellE>voxels</span> are shown.<o:p></o:p></span></p>
|
|---|
| 582 |
|
|---|
| 583 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 584 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB
|
|---|
| 585 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p>
|
|---|
| 586 |
|
|---|
| 587 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 588 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB
|
|---|
| 589 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p>
|
|---|
| 590 |
|
|---|
| 591 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 592 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB
|
|---|
| 593 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p>
|
|---|
| 594 |
|
|---|
| 595 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 596 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB
|
|---|
| 597 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p>
|
|---|
| 598 |
|
|---|
| 599 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 600 | mso-layout-grid-align:none;text-autospace:none'><b><span lang=EN-GB
|
|---|
| 601 | style='font-family:Arial;color:#66CCFF;mso-ansi-language:EN-GB'>PHYSICS<o:p></o:p></span></b></p>
|
|---|
| 602 |
|
|---|
| 603 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 604 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB
|
|---|
| 605 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p>
|
|---|
| 606 |
|
|---|
| 607 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 608 | mso-layout-grid-align:none;text-autospace:none'><b><span lang=EN-GB
|
|---|
| 609 | style='font-family:Arial;color:yellow;mso-ansi-language:EN-GB'>Low energy
|
|---|
| 610 | electromagnetic</span></b><span lang=EN-GB style='font-family:Arial;color:white;
|
|---|
| 611 | mso-ansi-language:EN-GB'> processes (for alphas, electrons, photons) and </span><span
|
|---|
| 612 | class=SpellE><b><span lang=EN-GB style='font-family:Arial;color:yellow;
|
|---|
| 613 | mso-ansi-language:EN-GB'>hadronic</span></b></span><b><span lang=EN-GB
|
|---|
| 614 | style='font-family:Arial;color:yellow;mso-ansi-language:EN-GB'> elastic and
|
|---|
| 615 | inelastic scattering</span></b><span lang=EN-GB style='font-family:Arial;
|
|---|
| 616 | color:white;mso-ansi-language:EN-GB'> for alphas are activated by default. Low
|
|---|
| 617 | energy electromagnetic electronic and nuclear stopping <span class=GramE>power
|
|---|
| 618 | are</span> computed from ICRU tables.<o:p></o:p></span></p>
|
|---|
| 619 |
|
|---|
| 620 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 621 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB
|
|---|
| 622 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><span
|
|---|
| 623 | style='mso-tab-count:1'> </span><o:p></o:p></span></p>
|
|---|
| 624 |
|
|---|
| 625 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 626 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB
|
|---|
| 627 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p>
|
|---|
| 628 |
|
|---|
| 629 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 630 | mso-layout-grid-align:none;text-autospace:none'><b><span lang=EN-GB
|
|---|
| 631 | style='font-family:Arial;color:#66CCFF;mso-ansi-language:EN-GB'>CODE DESIGN<o:p></o:p></span></b></p>
|
|---|
| 632 |
|
|---|
| 633 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 634 | mso-layout-grid-align:none;text-autospace:none'><b><span lang=EN-GB
|
|---|
| 635 | style='font-family:Arial;color:#66CCFF;mso-ansi-language:EN-GB'><o:p> </o:p></span></b></p>
|
|---|
| 636 |
|
|---|
| 637 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 638 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB
|
|---|
| 639 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>The <span
|
|---|
| 640 | class=SpellE>Microbeam</span> code design obtained from the Rational Rose
|
|---|
| 641 | software is shown below.<o:p></o:p></span></p>
|
|---|
| 642 |
|
|---|
| 643 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 644 | mso-layout-grid-align:none;text-autospace:none'><b><span lang=EN-GB
|
|---|
| 645 | style='font-family:Arial;color:#66CCFF;mso-ansi-language:EN-GB'><o:p> </o:p></span></b></p>
|
|---|
| 646 |
|
|---|
| 647 | <p class=MsoNormal align=center style='text-align:center;mso-layout-grid-align:
|
|---|
| 648 | none;text-autospace:none'><!--[if gte vml 1]><v:shape id="_x0000_i1031" type="#_x0000_t75"
|
|---|
| 649 | style='width:644.25pt;height:485.25pt;mso-position-horizontal-relative:text;
|
|---|
| 650 | mso-position-vertical-relative:text' o:allowoverlap="f">
|
|---|
| 651 | <v:imagedata src="microbeam_fichiers/image016.emz" o:title=""/>
|
|---|
| 652 | </v:shape><![endif]--><![if !vml]><img border=0 width=859 height=647
|
|---|
| 653 | src="microbeam_fichiers/image014.gif" v:shapes="_x0000_i1031"><![endif]><span
|
|---|
| 654 | lang=EN-GB style='mso-ansi-language:EN-GB'><o:p></o:p></span></p>
|
|---|
| 655 |
|
|---|
| 656 | <p class=MsoNormal align=center style='text-align:center;mso-layout-grid-align:
|
|---|
| 657 | none;text-autospace:none'><span lang=EN-GB style='mso-ansi-language:EN-GB'><o:p> </o:p></span></p>
|
|---|
| 658 |
|
|---|
| 659 | <p class=MsoNormal align=center style='text-align:center;mso-layout-grid-align:
|
|---|
| 660 | none;text-autospace:none'><span class=GramE><span lang=EN-GB style='font-family:
|
|---|
| 661 | Arial;color:#CCFFCC;mso-ansi-language:EN-GB'>Rational Rose class diagram of the
|
|---|
| 662 | <span class=SpellE>Microbeam</span> example.</span></span><span lang=EN-GB
|
|---|
| 663 | style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'> <o:p></o:p></span></p>
|
|---|
| 664 |
|
|---|
| 665 | <p class=MsoNormal align=center style='text-align:center;mso-layout-grid-align:
|
|---|
| 666 | none;text-autospace:none'><span lang=EN-GB style='font-family:Arial;color:#CCFFCC;
|
|---|
| 667 | mso-ansi-language:EN-GB'>Manager classes are filled with red and <span
|
|---|
| 668 | class=SpellE>Microbeam</span> classes are filled with sky blue.</span><b><span
|
|---|
| 669 | lang=EN-GB style='font-family:Arial;color:#66CCFF;mso-ansi-language:EN-GB'><o:p></o:p></span></b></p>
|
|---|
| 670 |
|
|---|
| 671 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 672 | mso-layout-grid-align:none;text-autospace:none'><b><span lang=EN-GB
|
|---|
| 673 | style='font-family:Arial;color:#66CCFF;mso-ansi-language:EN-GB'><o:p> </o:p></span></b></p>
|
|---|
| 674 |
|
|---|
| 675 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 676 | mso-layout-grid-align:none;text-autospace:none'><b><span lang=EN-GB
|
|---|
| 677 | style='font-family:Arial;color:#66CCFF;mso-ansi-language:EN-GB'><o:p> </o:p></span></b></p>
|
|---|
| 678 |
|
|---|
| 679 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 680 | mso-layout-grid-align:none;text-autospace:none'><b><span lang=EN-GB
|
|---|
| 681 | style='font-family:Arial;color:#66CCFF;mso-ansi-language:EN-GB'>SUGGESTED
|
|---|
| 682 | PAPERS ABOUT THIS SIMULATION AND ITS VALIDATION<o:p></o:p></span></b></p>
|
|---|
| 683 |
|
|---|
| 684 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 685 | mso-layout-grid-align:none;text-autospace:none'><b><span lang=EN-GB
|
|---|
| 686 | style='font-family:Arial;color:#66CCFF;mso-ansi-language:EN-GB'><o:p> </o:p></span></b></p>
|
|---|
| 687 |
|
|---|
| 688 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 689 | mso-layout-grid-align:none;text-autospace:none'><b><span lang=EN-GB
|
|---|
| 690 | style='font-family:Arial;color:yellow;mso-ansi-language:EN-GB'><span
|
|---|
| 691 | style='mso-tab-count:1'> </span>These papers can be accessed online
|
|---|
| 692 | at the SLAC-SPIRES online database by clicking </span></b><b><span lang=EN-GB
|
|---|
| 693 | style='font-family:Arial;color:red;mso-ansi-language:EN-GB'><a
|
|---|
| 694 | href="http://www.slac.stanford.edu/spires/find/hep/www?rawcmd=find+a+incerti&FORMAT=WWW&SEQUENCE="><span
|
|---|
| 695 | style='color:red'>here</span></a></span></b><b><span lang=EN-GB
|
|---|
| 696 | style='font-family:Arial;color:yellow;mso-ansi-language:EN-GB'> <o:p></o:p></span></b></p>
|
|---|
| 697 |
|
|---|
| 698 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 699 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB
|
|---|
| 700 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p>
|
|---|
| 701 |
|
|---|
| 702 | <p class=MsoNormal style='margin-left:35.4pt'><span lang=EN-GB
|
|---|
| 703 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>►</span><span
|
|---|
| 704 | lang=EN-GB style='font-family:Arial;color:#CC99FF;mso-ansi-language:EN-GB'> <b
|
|---|
| 705 | style='mso-bidi-font-weight:normal'><span style='text-transform:uppercase'>Monte
|
|---|
| 706 | Carlo microdosimetry for targeted irradiation of individual cells using a
|
|---|
| 707 | microbeam facility</span></b></span><span lang=EN-GB style='font-family:Arial;
|
|---|
| 708 | color:white;mso-ansi-language:EN-GB'> <o:p></o:p></span></p>
|
|---|
| 709 |
|
|---|
| 710 | <p class=MsoNormal style='margin-left:35.4pt'><span lang=EN-GB
|
|---|
| 711 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>By </span><st1:place><span
|
|---|
| 712 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>S.
|
|---|
| 713 | Incerti</span></st1:place><span lang=EN-GB style='font-family:Arial;
|
|---|
| 714 | color:white;mso-ansi-language:EN-GB'>, T. <span class=SpellE>Pouthier</span>,
|
|---|
| 715 | H. <span class=SpellE>Seznec</span>, Ph. </span><span lang=IT style='font-family:
|
|---|
| 716 | Arial;color:white;mso-ansi-language:IT'>Moretto, O. Boissonnade, T. M. H.
|
|---|
| 717 | Ha, F. Andersson, Ph. </span><span class=SpellE><span lang=EN-GB
|
|---|
| 718 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>Barberet</span></span><span
|
|---|
| 719 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>, C. <span
|
|---|
| 720 | class=SpellE>Habchi</span> and D. T. Nguyen <o:p></o:p></span></p>
|
|---|
| 721 |
|
|---|
| 722 | <p class=MsoNormal style='margin-left:35.4pt'><strong><span lang=EN-GB
|
|---|
| 723 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB;font-weight:normal;
|
|---|
| 724 | mso-bidi-font-weight:bold'>In preparation</span></strong><strong><span
|
|---|
| 725 | lang=EN-GB style='font-family:Arial;color:#FF9900;mso-ansi-language:EN-GB'>
|
|---|
| 726 | (2007)</span></strong><strong><span lang=EN-GB style='mso-ansi-language:EN-GB'><o:p></o:p></span></strong></p>
|
|---|
| 727 |
|
|---|
| 728 | <p class=MsoNormal><strong><span lang=EN-GB style='font-family:Arial;
|
|---|
| 729 | color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></strong></p>
|
|---|
| 730 |
|
|---|
| 731 | <p class=MsoNormal style='margin-left:35.4pt'><span lang=EN-GB
|
|---|
| 732 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>►</span><span
|
|---|
| 733 | lang=EN-GB style='font-family:Arial;color:#CC99FF;mso-ansi-language:EN-GB'> <b><span
|
|---|
| 734 | style='text-transform:uppercase'>Monte Carlo simulation of the CENBG microbeam
|
|---|
| 735 | and nanobeam lines with the Geant4 toolkit</span></b></span><span lang=EN-GB
|
|---|
| 736 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'> <br>
|
|---|
| 737 | By <span style='mso-bidi-font-weight:bold'>S</span>. <span style='mso-bidi-font-weight:
|
|---|
| 738 | bold'>Incerti</span>, Q. Zhang, F. <span class=SpellE>Andersson</span>, Ph. <span
|
|---|
| 739 | class=SpellE>Moretto</span>, G.W. Grime, M.J. Merchant, D.T. Nguyen, C. <span
|
|---|
| 740 | class=SpellE>Habchi</span>, T. <span class=SpellE>Pouthier</span> and H. <span
|
|---|
| 741 | class=SpellE>Seznec</span></span><span lang=EN-GB style='mso-ansi-language:
|
|---|
| 742 | EN-GB'><o:p></o:p></span></p>
|
|---|
| 743 |
|
|---|
| 744 | <p class=MsoNormal style='margin-left:35.4pt;text-align:justify;text-justify:
|
|---|
| 745 | inter-ideograph;mso-layout-grid-align:none;text-autospace:none'><span
|
|---|
| 746 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>In
|
|---|
| 747 | press in </span><span class=SpellE><b><span lang=EN-GB style='font-family:Arial;
|
|---|
| 748 | color:#FF9933;mso-ansi-language:EN-GB'>Nucl.Instrum.Meth.B</span></b></span><b><span
|
|---|
| 749 | lang=EN-GB style='font-family:Arial;color:#FF9933;mso-ansi-language:EN-GB'>,
|
|---|
| 750 | 2007<o:p></o:p></span></b></p>
|
|---|
| 751 |
|
|---|
| 752 | <p class=MsoNormal style='margin-left:35.4pt;text-align:justify;text-justify:
|
|---|
| 753 | inter-ideograph;mso-layout-grid-align:none;text-autospace:none'><span
|
|---|
| 754 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p>
|
|---|
| 755 |
|
|---|
| 756 | <p class=MsoNormal style='margin-left:35.4pt;mso-layout-grid-align:none;
|
|---|
| 757 | text-autospace:none'><span lang=EN-GB style='font-family:Arial;color:white;
|
|---|
| 758 | mso-ansi-language:EN-GB'>►</span><span lang=EN-GB style='font-family:
|
|---|
| 759 | Arial;color:#CC99FF;mso-ansi-language:EN-GB'> <b><span style='text-transform:
|
|---|
| 760 | uppercase'>A Comparison of cellular irradiation techniques with alpha particles
|
|---|
| 761 | using the Geant4 Monte Carlo simulation toolkit</span></b></span><span
|
|---|
| 762 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><br>
|
|---|
| 763 | By </span><span style='font-family:Arial;color:white'><a
|
|---|
| 764 | href="http://www.slac.stanford.edu/spires/find/wwwhepau/wwwscan?rawcmd=fin+%22Incerti%2C%20S%2E%22"><span
|
|---|
| 765 | lang=EN-GB style='color:white;mso-ansi-language:EN-GB;text-decoration:none;
|
|---|
| 766 | text-underline:none'>S. Incerti</span></a></span><span lang=EN-GB
|
|---|
| 767 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>, </span><span
|
|---|
| 768 | style='font-family:Arial;color:white'><a
|
|---|
| 769 | href="http://www.slac.stanford.edu/spires/find/wwwhepau/wwwscan?rawcmd=fin+%22Gault%2C%20N%2E%22"><span
|
|---|
| 770 | lang=EN-GB style='color:white;mso-ansi-language:EN-GB;text-decoration:none;
|
|---|
| 771 | text-underline:none'>N. <span class=SpellE>Gault</span></span></a></span><span
|
|---|
| 772 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>, </span><span
|
|---|
| 773 | style='font-family:Arial;color:white'><a
|
|---|
| 774 | href="http://www.slac.stanford.edu/spires/find/wwwhepau/wwwscan?rawcmd=fin+%22Habchi%2C%20C%2E%22"><span
|
|---|
| 775 | lang=EN-GB style='color:white;mso-ansi-language:EN-GB;text-decoration:none;
|
|---|
| 776 | text-underline:none'>C. <span class=SpellE>Habchi</span></span></a></span><span
|
|---|
| 777 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>, </span><span
|
|---|
| 778 | style='font-family:Arial;color:white'><a
|
|---|
| 779 | href="http://www.slac.stanford.edu/spires/find/wwwhepau/wwwscan?rawcmd=fin+%22Lefaix%2C%20J%2EL%2E%2E%22"><span
|
|---|
| 780 | lang=EN-GB style='color:white;mso-ansi-language:EN-GB;text-decoration:none;
|
|---|
| 781 | text-underline:none'>J.L.. <span class=SpellE>Lefaix</span></span></a></span><span
|
|---|
| 782 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>, </span><span
|
|---|
| 783 | style='font-family:Arial;color:white'><a
|
|---|
| 784 | href="http://www.slac.stanford.edu/spires/find/wwwhepau/wwwscan?rawcmd=fin+%22Moretto%2C%20Ph%2E%22"><span
|
|---|
| 785 | lang=EN-GB style='color:white;mso-ansi-language:EN-GB;text-decoration:none;
|
|---|
| 786 | text-underline:none'>Ph. <span class=SpellE>Moretto</span></span></a></span><span
|
|---|
| 787 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>, </span><span
|
|---|
| 788 | style='font-family:Arial;color:white'><a
|
|---|
| 789 | href="http://www.slac.stanford.edu/spires/find/wwwhepau/wwwscan?rawcmd=fin+%22Poncy%2C%20J%2EL%2E%2E%22"><span
|
|---|
| 790 | class=GramE><span lang=EN-GB style='color:white;mso-ansi-language:EN-GB;
|
|---|
| 791 | text-decoration:none;text-underline:none'>J.L..</span></span><span lang=EN-GB
|
|---|
| 792 | style='color:white;mso-ansi-language:EN-GB;text-decoration:none;text-underline:
|
|---|
| 793 | none'> <span class=SpellE>Poncy</span></span></a></span><span lang=EN-GB
|
|---|
| 794 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>, </span><span
|
|---|
| 795 | style='font-family:Arial;color:white'><a
|
|---|
| 796 | href="http://www.slac.stanford.edu/spires/find/wwwhepau/wwwscan?rawcmd=fin+%22Pouthier%2C%20T%2E%22"><span
|
|---|
| 797 | lang=EN-GB style='color:white;mso-ansi-language:EN-GB;text-decoration:none;
|
|---|
| 798 | text-underline:none'>T. <span class=SpellE>Pouthier</span></span></a></span><span
|
|---|
| 799 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>, </span><span
|
|---|
| 800 | style='font-family:Arial;color:white'><a
|
|---|
| 801 | href="http://www.slac.stanford.edu/spires/find/wwwhepau/wwwscan?rawcmd=fin+%22Seznec%2C%20H%2E%22"><span
|
|---|
| 802 | lang=EN-GB style='color:white;mso-ansi-language:EN-GB;text-decoration:none;
|
|---|
| 803 | text-underline:none'>H. <span class=SpellE>Seznec</span></span></a></span><span
|
|---|
| 804 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>. Dec
|
|---|
| 805 | 2006. 3pp<span class=GramE>.</span><br>
|
|---|
| 806 | Published in </span><b style='mso-bidi-font-weight:normal'><span lang=EN-GB
|
|---|
| 807 | style='font-family:Arial;color:#FF9900;mso-ansi-language:EN-GB'>Rad.Prot.Dos.,1-3,2006
|
|---|
| 808 | (Micros 2005 special issue)</span></b><span lang=EN-GB style='font-family:Arial;
|
|---|
| 809 | color:white;mso-ansi-language:EN-GB'>.<o:p></o:p></span></p>
|
|---|
| 810 |
|
|---|
| 811 | <p class=MsoNormal style='margin-left:35.4pt;text-align:justify;text-justify:
|
|---|
| 812 | inter-ideograph;mso-layout-grid-align:none;text-autospace:none'><span
|
|---|
| 813 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p>
|
|---|
| 814 |
|
|---|
| 815 | <p class=MsoNormal style='margin-left:35.4pt;text-align:justify;text-justify:
|
|---|
| 816 | inter-ideograph;mso-layout-grid-align:none;text-autospace:none'><span
|
|---|
| 817 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>►</span><span
|
|---|
| 818 | lang=EN-GB style='font-family:Arial;color:#CC99FF;mso-ansi-language:EN-GB'> <b>GEANT4
|
|---|
| 819 | SIMULATION OF THE NEW CENBG MICRO AND NANO PROBES FACILITY<o:p></o:p></b></span></p>
|
|---|
| 820 |
|
|---|
| 821 | <p class=MsoNormal style='margin-left:35.4pt;text-align:justify;text-justify:
|
|---|
| 822 | inter-ideograph;mso-layout-grid-align:none;text-autospace:none'><span
|
|---|
| 823 | class=GramE><span lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:
|
|---|
| 824 | EN-GB'>By </span></span><st1:place><span class=GramE><span lang=EN-GB
|
|---|
| 825 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>S. Incerti</span></span></st1:place><span
|
|---|
| 826 | class=GramE><span lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:
|
|---|
| 827 | EN-GB'>, C. Habchi, Ph. Moretto, J. Olivier and H. <span class=SpellE>Seznec</span>.</span></span><span
|
|---|
| 828 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'> May
|
|---|
| 829 | 2006. 5pp.<o:p></o:p></span></p>
|
|---|
| 830 |
|
|---|
| 831 | <p class=MsoNormal style='margin-left:35.4pt;text-align:justify;text-justify:
|
|---|
| 832 | inter-ideograph;mso-layout-grid-align:none;text-autospace:none'><span
|
|---|
| 833 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>Published
|
|---|
| 834 | in </span><b><span lang=EN-GB style='font-family:Arial;color:#FF9933;
|
|---|
| 835 | mso-ansi-language:EN-GB'>Nucl.Instrum.Meth.B249:738-742, 2006</span></b><b><span
|
|---|
| 836 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p></o:p></span></b></p>
|
|---|
| 837 |
|
|---|
| 838 | <p class=MsoNormal style='margin-left:35.4pt;text-align:justify;text-justify:
|
|---|
| 839 | inter-ideograph;mso-layout-grid-align:none;text-autospace:none'><span
|
|---|
| 840 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p>
|
|---|
| 841 |
|
|---|
| 842 | <p class=MsoNormal style='margin-left:35.4pt;mso-layout-grid-align:none;
|
|---|
| 843 | text-autospace:none'><span lang=EN-GB style='font-family:Arial;color:white;
|
|---|
| 844 | mso-ansi-language:EN-GB'>►</span><span lang=EN-GB style='font-family:
|
|---|
| 845 | Arial;color:#CC99FF;mso-ansi-language:EN-GB'> <span class=GramE><b><span
|
|---|
| 846 | style='text-transform:uppercase'>A</span></b></span><b><span style='text-transform:
|
|---|
| 847 | uppercase'> Comparison of ray-tracing software for the design of quadrupole
|
|---|
| 848 | microbeam systems</span></b><span style='text-transform:uppercase'><br>
|
|---|
| 849 | </span></span><span lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:
|
|---|
| 850 | EN-GB'>By S. Incerti et al., <br>
|
|---|
| 851 | Published </span><span lang=EN-GB style='font-family:Arial;color:#FF9900;
|
|---|
| 852 | mso-ansi-language:EN-GB'>in <b>Nucl.Instrum.Meth.B231:76-85, 2005</b></span><b><span
|
|---|
| 853 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p></o:p></span></b></p>
|
|---|
| 854 |
|
|---|
| 855 | <p class=MsoNormal style='margin-left:35.4pt;mso-layout-grid-align:none;
|
|---|
| 856 | text-autospace:none'><b><span lang=EN-GB style='font-family:Arial;color:white;
|
|---|
| 857 | mso-ansi-language:EN-GB'><o:p> </o:p></span></b></p>
|
|---|
| 858 |
|
|---|
| 859 | <p class=MsoNormal style='margin-left:35.4pt;text-align:justify;text-justify:
|
|---|
| 860 | inter-ideograph;mso-layout-grid-align:none;text-autospace:none'><span
|
|---|
| 861 | class=GramE><span lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:
|
|---|
| 862 | EN-GB'>►</span><span lang=EN-GB style='font-family:Arial;color:#CC99FF;
|
|---|
| 863 | mso-ansi-language:EN-GB'> <b>DEVELOPMENT OF A FOCUSED CHARGED PARTICLE
|
|---|
| 864 | MICROBEAM FOR THE IRRADIATION OF INDIVIDUAL CELLS.</b></span></span><b><span
|
|---|
| 865 | lang=EN-GB style='font-family:Arial;color:#CC99FF;mso-ansi-language:EN-GB'><o:p></o:p></span></b></p>
|
|---|
| 866 |
|
|---|
| 867 | <p class=MsoNormal style='margin-left:35.4pt;text-align:justify;text-justify:
|
|---|
| 868 | inter-ideograph;mso-layout-grid-align:none;text-autospace:none'><span
|
|---|
| 869 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>By Ph.
|
|---|
| 870 | <span class=SpellE>Barberet</span>, A. <span class=SpellE>Balana</span>, S.
|
|---|
| 871 | Incerti, C. <span class=SpellE>Michelet-Habchi</span>, Ph. Moretto, Th. <span
|
|---|
| 872 | class=SpellE>Pouthier</span>. Dec 2004. 6pp. <o:p></o:p></span></p>
|
|---|
| 873 |
|
|---|
| 874 | <p class=MsoNormal style='margin-left:35.4pt;text-align:justify;text-justify:
|
|---|
| 875 | inter-ideograph;mso-layout-grid-align:none;text-autospace:none'><span
|
|---|
| 876 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>Published
|
|---|
| 877 | in </span><b><span lang=EN-GB style='font-family:Arial;color:#FF9933;
|
|---|
| 878 | mso-ansi-language:EN-GB'>Rev.Sci.Instrum.76:015101, 2005<o:p></o:p></span></b></p>
|
|---|
| 879 |
|
|---|
| 880 | <p class=MsoNormal style='margin-left:35.4pt;text-align:justify;text-justify:
|
|---|
| 881 | inter-ideograph;mso-layout-grid-align:none;text-autospace:none'><span
|
|---|
| 882 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p>
|
|---|
| 883 |
|
|---|
| 884 | <p class=MsoNormal style='margin-left:35.4pt;text-align:justify;text-justify:
|
|---|
| 885 | inter-ideograph;mso-layout-grid-align:none;text-autospace:none'><span
|
|---|
| 886 | class=GramE><span lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:
|
|---|
| 887 | EN-GB'>► </span><b><span lang=EN-GB style='font-family:Arial;color:#CC99FF;
|
|---|
| 888 | mso-ansi-language:EN-GB'>SIMULATION OF CELLULAR IRRADIATION WITH THE CENBG
|
|---|
| 889 | MICROBEAM LINE USING GEANT4.</span></b></span><b><span lang=EN-GB
|
|---|
| 890 | style='font-family:Arial;color:#CC99FF;mso-ansi-language:EN-GB'><o:p></o:p></span></b></p>
|
|---|
| 891 |
|
|---|
| 892 | <p class=MsoNormal style='margin-left:35.4pt;text-align:justify;text-justify:
|
|---|
| 893 | inter-ideograph;mso-layout-grid-align:none;text-autospace:none'><span
|
|---|
| 894 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>By S.
|
|---|
| 895 | Incerti, Ph. <span class=SpellE>Barberet</span>, R. <span class=SpellE>Villeneuve</span>,
|
|---|
| 896 | P. <span class=SpellE>Aguer</span>, E. <span class=SpellE>Gontier</span>, C. <span
|
|---|
| 897 | class=SpellE>Michelet-Habchi</span>, Ph. Moretto, D.T. Nguyen, T. <span
|
|---|
| 898 | class=SpellE>Pouthier</span>, R.W. Smith. Oct 2003. 6pp. <o:p></o:p></span></p>
|
|---|
| 899 |
|
|---|
| 900 | <p class=MsoNormal style='margin-left:35.4pt;text-align:justify;text-justify:
|
|---|
| 901 | inter-ideograph;mso-layout-grid-align:none;text-autospace:none'><span
|
|---|
| 902 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>Published
|
|---|
| 903 | in </span><b><span lang=EN-GB style='font-family:Arial;color:#FF9933;
|
|---|
| 904 | mso-ansi-language:EN-GB'>IEEE Trans.Nucl.Sci.51:1395-1401, 2004</span></b><span
|
|---|
| 905 | lang=EN-GB style='font-family:Arial;color:#FF9933;mso-ansi-language:EN-GB'><o:p></o:p></span></p>
|
|---|
| 906 |
|
|---|
| 907 | <p class=MsoNormal style='margin-left:35.4pt;text-align:justify;text-justify:
|
|---|
| 908 | inter-ideograph;mso-layout-grid-align:none;text-autospace:none'><span
|
|---|
| 909 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p>
|
|---|
| 910 |
|
|---|
| 911 | <p class=MsoNormal style='margin-left:35.4pt;mso-layout-grid-align:none;
|
|---|
| 912 | text-autospace:none'><span class=GramE><span lang=EN-GB style='font-family:
|
|---|
| 913 | Arial;color:white;mso-ansi-language:EN-GB'>►</span><span lang=EN-GB
|
|---|
| 914 | style='font-family:Arial;color:#CC99FF;mso-ansi-language:EN-GB'> <b>SIMULATION
|
|---|
| 915 | OF ION PROPAGATION IN THE MICROBEAM LINE OF CENBG USING GEANT4.</b></span></span><span
|
|---|
| 916 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><br>
|
|---|
| 917 | By </span><span style='font-family:Arial;color:white'><a
|
|---|
| 918 | href="http://www.slac.stanford.edu/spires/find/wwwhepau/wwwscan?rawcmd=fin+%22Incerti,+S.%22"><span
|
|---|
| 919 | lang=EN-GB style='color:white;mso-ansi-language:EN-GB;text-decoration:none;
|
|---|
| 920 | text-underline:none'>S. Incerti</span></a></span><span lang=EN-GB
|
|---|
| 921 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>, </span><span
|
|---|
| 922 | style='font-family:Arial;color:white'><a
|
|---|
| 923 | href="http://www.slac.stanford.edu/spires/find/wwwhepau/wwwscan?rawcmd=fin+%22Barberet,+Ph.%22"><span
|
|---|
| 924 | lang=EN-GB style='color:white;mso-ansi-language:EN-GB;text-decoration:none;
|
|---|
| 925 | text-underline:none'>Ph. <span class=SpellE>Barberet</span></span></a></span><span
|
|---|
| 926 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>, </span><span
|
|---|
| 927 | style='font-family:Arial;color:white'><a
|
|---|
| 928 | href="http://www.slac.stanford.edu/spires/find/wwwhepau/wwwscan?rawcmd=fin+%22Courtois,+B.%22"><span
|
|---|
| 929 | lang=EN-GB style='color:white;mso-ansi-language:EN-GB;text-decoration:none;
|
|---|
| 930 | text-underline:none'>B. <span class=SpellE>Courtois</span></span></a></span><span
|
|---|
| 931 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>, </span><span
|
|---|
| 932 | style='font-family:Arial;color:white'><a
|
|---|
| 933 | href="http://www.slac.stanford.edu/spires/find/wwwhepau/wwwscan?rawcmd=fin+%22Michelet-Habchi,+C.%22"><span
|
|---|
| 934 | lang=EN-GB style='color:white;mso-ansi-language:EN-GB;text-decoration:none;
|
|---|
| 935 | text-underline:none'>C. <span class=SpellE>Michelet-Habchi</span></span></a></span><span
|
|---|
| 936 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>, </span><span
|
|---|
| 937 | style='font-family:Arial;color:white'><a
|
|---|
| 938 | href="http://www.slac.stanford.edu/spires/find/wwwhepau/wwwscan?rawcmd=fin+%22Moretto,+Ph.%22"><span
|
|---|
| 939 | lang=EN-GB style='color:white;mso-ansi-language:EN-GB;text-decoration:none;
|
|---|
| 940 | text-underline:none'>Ph. <span class=SpellE>Moretto</span></span></a></span><span
|
|---|
| 941 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>. Sep
|
|---|
| 942 | 2003. <br>
|
|---|
| 943 | Published in </span><b><span lang=EN-GB style='font-family:Arial;color:#FF9933;
|
|---|
| 944 | mso-ansi-language:EN-GB'>Nucl.Instrum.Meth.B210:92-97, 2003</span></b><span
|
|---|
| 945 | lang=EN-GB style='font-family:Arial;color:#FFCCFF;mso-ansi-language:EN-GB'><o:p></o:p></span></p>
|
|---|
| 946 |
|
|---|
| 947 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 948 | mso-layout-grid-align:none;text-autospace:none'><b><span lang=EN-GB
|
|---|
| 949 | style='font-family:Arial;color:#66CCFF;mso-ansi-language:EN-GB'><o:p> </o:p></span></b></p>
|
|---|
| 950 |
|
|---|
| 951 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 952 | mso-layout-grid-align:none;text-autospace:none'><b><span lang=EN-GB
|
|---|
| 953 | style='font-family:Arial;color:#66CCFF;mso-ansi-language:EN-GB'><o:p> </o:p></span></b></p>
|
|---|
| 954 |
|
|---|
| 955 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 956 | mso-layout-grid-align:none;text-autospace:none'><b><span lang=EN-GB
|
|---|
| 957 | style='font-family:Arial;color:#66CCFF;mso-ansi-language:EN-GB'>HOW TO INSTALL
|
|---|
| 958 | AND RUN THE EXAMPLE<o:p></o:p></span></b></p>
|
|---|
| 959 |
|
|---|
| 960 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 961 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB
|
|---|
| 962 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p>
|
|---|
| 963 |
|
|---|
| 964 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 965 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB
|
|---|
| 966 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>Please, look at
|
|---|
| 967 | the </span><b><span lang=EN-GB style='font-family:Arial;color:yellow;
|
|---|
| 968 | mso-ansi-language:EN-GB'>README file</span></b><span lang=EN-GB
|
|---|
| 969 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'> provided with
|
|---|
| 970 | the example.<o:p></o:p></span></p>
|
|---|
| 971 |
|
|---|
| 972 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 973 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB
|
|---|
| 974 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p>
|
|---|
| 975 |
|
|---|
| 976 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 977 | mso-layout-grid-align:none;text-autospace:none'><b><span lang=EN-GB
|
|---|
| 978 | style='font-family:Arial;color:#66CCFF;mso-ansi-language:EN-GB'><o:p> </o:p></span></b></p>
|
|---|
| 979 |
|
|---|
| 980 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 981 | mso-layout-grid-align:none;text-autospace:none'><b><span lang=EN-GB
|
|---|
| 982 | style='font-family:Arial;color:#66CCFF;mso-ansi-language:EN-GB'>SIMULATION
|
|---|
| 983 | RESULTS<o:p></o:p></span></b></p>
|
|---|
| 984 |
|
|---|
| 985 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 986 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB
|
|---|
| 987 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p>
|
|---|
| 988 |
|
|---|
| 989 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 990 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB
|
|---|
| 991 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>This example does
|
|---|
| 992 | not need any external analysis tool. The output consists in several text
|
|---|
| 993 | (*.txt) files which are created directly in the <span class=SpellE>microbeam</span>
|
|---|
| 994 | <span class=GramE>directory :</span><o:p></o:p></span></p>
|
|---|
| 995 |
|
|---|
| 996 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 997 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB
|
|---|
| 998 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p>
|
|---|
| 999 |
|
|---|
| 1000 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 1001 | text-indent:35.4pt;mso-layout-grid-align:none;text-autospace:none'><span
|
|---|
| 1002 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>►
|
|---|
| 1003 | </span><span class=GramE><b><span lang=EN-GB style='font-family:Arial;
|
|---|
| 1004 | color:#CC99FF;mso-ansi-language:EN-GB'>dose.txt</span></b><span lang=EN-GB
|
|---|
| 1005 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'> :</span></span><span
|
|---|
| 1006 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'> gives
|
|---|
| 1007 | the total deposited dose in the cell nucleus and in the cell cytoplasm for each
|
|---|
| 1008 | incident alpha particle;<o:p></o:p></span></p>
|
|---|
| 1009 |
|
|---|
| 1010 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 1011 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB
|
|---|
| 1012 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p>
|
|---|
| 1013 |
|
|---|
| 1014 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 1015 | text-indent:35.4pt;mso-layout-grid-align:none;text-autospace:none'><span
|
|---|
| 1016 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>►
|
|---|
| 1017 | </span><span class=GramE><b><span lang=EN-GB style='font-family:Arial;
|
|---|
| 1018 | color:#CC99FF;mso-ansi-language:EN-GB'>3DDose.txt</span></b><span lang=EN-GB
|
|---|
| 1019 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'> :</span></span><span
|
|---|
| 1020 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'> gives
|
|---|
| 1021 | the average dose deposited per <span class=SpellE>voxel</span> per incident
|
|---|
| 1022 | alpha particle;<o:p></o:p></span></p>
|
|---|
| 1023 |
|
|---|
| 1024 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 1025 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB
|
|---|
| 1026 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p>
|
|---|
| 1027 |
|
|---|
| 1028 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 1029 | text-indent:35.4pt;mso-layout-grid-align:none;text-autospace:none'><span
|
|---|
| 1030 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>►
|
|---|
| 1031 | </span><span class=GramE><b><span lang=EN-GB style='font-family:Arial;
|
|---|
| 1032 | color:#CC99FF;mso-ansi-language:EN-GB'>range.txt</span></b><span lang=EN-GB
|
|---|
| 1033 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'> :</span></span><span
|
|---|
| 1034 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>
|
|---|
| 1035 | indicates the final stopping (<span class=SpellE>x,y,z</span>) position of the
|
|---|
| 1036 | incident alpha particle within the irradiated medium (cell or culture medium)<o:p></o:p></span></p>
|
|---|
| 1037 |
|
|---|
| 1038 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 1039 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB
|
|---|
| 1040 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p>
|
|---|
| 1041 |
|
|---|
| 1042 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 1043 | text-indent:35.4pt;mso-layout-grid-align:none;text-autospace:none'><span
|
|---|
| 1044 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>►
|
|---|
| 1045 | </span><span class=GramE><b><span lang=EN-GB style='font-family:Arial;
|
|---|
| 1046 | color:#CC99FF;mso-ansi-language:EN-GB'>stoppingPower.txt</span></b><span
|
|---|
| 1047 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'> :</span></span><span
|
|---|
| 1048 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'> gives
|
|---|
| 1049 | the actual stopping power <span class=SpellE>dE/dx</span> of the incident alpha
|
|---|
| 1050 | particle just before penetrating into the targeted cell;<o:p></o:p></span></p>
|
|---|
| 1051 |
|
|---|
| 1052 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 1053 | text-indent:35.4pt;mso-layout-grid-align:none;text-autospace:none'><span
|
|---|
| 1054 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p>
|
|---|
| 1055 |
|
|---|
| 1056 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 1057 | text-indent:35.4pt;mso-layout-grid-align:none;text-autospace:none'><span
|
|---|
| 1058 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>►
|
|---|
| 1059 | </span><span class=GramE><b><span lang=EN-GB style='font-family:Arial;
|
|---|
| 1060 | color:#CC99FF;mso-ansi-language:EN-GB'>beamPosition.txt</span></b><span
|
|---|
| 1061 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'> :</span></span><span
|
|---|
| 1062 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'> gives
|
|---|
| 1063 | the beam transverse position distribution (X and Y) just before penetrating
|
|---|
| 1064 | into the targeted cell;<o:p></o:p></span></p>
|
|---|
| 1065 |
|
|---|
| 1066 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 1067 | text-indent:35.4pt;mso-layout-grid-align:none;text-autospace:none'><span
|
|---|
| 1068 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p>
|
|---|
| 1069 |
|
|---|
| 1070 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 1071 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB
|
|---|
| 1072 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p>
|
|---|
| 1073 |
|
|---|
| 1074 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 1075 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB
|
|---|
| 1076 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>These files can
|
|---|
| 1077 | be easily analyzed using the provided </span><b><span lang=EN-GB
|
|---|
| 1078 | style='font-family:Arial;color:yellow;mso-ansi-language:EN-GB'>ROOT macro file</span></b><span
|
|---|
| 1079 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'> </span><span
|
|---|
| 1080 | class=SpellE><b><span lang=EN-GB style='font-family:Arial;color:yellow;
|
|---|
| 1081 | mso-ansi-language:EN-GB'>plot.C</span></b></span><span lang=EN-GB
|
|---|
| 1082 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>. Fore more
|
|---|
| 1083 | details, please refer to the </span><b><span lang=EN-GB style='font-family:
|
|---|
| 1084 | Arial;color:yellow;mso-ansi-language:EN-GB'>README file</span></b><span
|
|---|
| 1085 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>. The
|
|---|
| 1086 | ROOT website is available <span class=GramE>at :</span> </span><b><span
|
|---|
| 1087 | lang=EN-GB style='font-family:Arial;color:aqua;mso-ansi-language:EN-GB'><a
|
|---|
| 1088 | href="http://root.cern.ch/"><span style='color:aqua;text-decoration:none;
|
|---|
| 1089 | text-underline:none'>http://root.cern.ch</span></a></span></b><span lang=EN-GB
|
|---|
| 1090 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>. The macro gives
|
|---|
| 1091 | the following graphical <span class=GramE>output :</span><o:p></o:p></span></p>
|
|---|
| 1092 |
|
|---|
| 1093 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 1094 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB
|
|---|
| 1095 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p>
|
|---|
| 1096 |
|
|---|
| 1097 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 1098 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB
|
|---|
| 1099 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p>
|
|---|
| 1100 |
|
|---|
| 1101 | <p class=MsoNormal align=center style='text-align:center;mso-layout-grid-align:
|
|---|
| 1102 | none;text-autospace:none'><!--[if gte vml 1]><v:shape id="_x0000_i1032" type="#_x0000_t75"
|
|---|
| 1103 | style='width:691.5pt;height:506.25pt;mso-position-horizontal-relative:text;
|
|---|
| 1104 | mso-position-vertical-relative:text' o:allowoverlap="f">
|
|---|
| 1105 | <v:imagedata src="microbeam_fichiers/image019.emz" o:title=""/>
|
|---|
| 1106 | </v:shape><![endif]--><![if !vml]><img border=0 width=922 height=675
|
|---|
| 1107 | src="microbeam_fichiers/image013.gif" v:shapes="_x0000_i1032"><![endif]><span
|
|---|
| 1108 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p></o:p></span></p>
|
|---|
| 1109 |
|
|---|
| 1110 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm;
|
|---|
| 1111 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB
|
|---|
| 1112 | style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'><o:p> </o:p></span></p>
|
|---|
| 1113 |
|
|---|
| 1114 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm;
|
|---|
| 1115 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB
|
|---|
| 1116 | style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'>Typical
|
|---|
| 1117 | graphical output from the <span class=SpellE><b>plot.C</b></span> macro file
|
|---|
| 1118 | obtained for 2x10<sup>4</sup> incident alpha <span class=GramE>particles :</span><o:p></o:p></span></p>
|
|---|
| 1119 |
|
|---|
| 1120 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm;
|
|---|
| 1121 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB
|
|---|
| 1122 | style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'><o:p> </o:p></span></p>
|
|---|
| 1123 |
|
|---|
| 1124 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm;
|
|---|
| 1125 | mso-layout-grid-align:none;text-autospace:none'><b><span lang=EN-GB
|
|---|
| 1126 | style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'>TOP row <o:p></o:p></span></b></p>
|
|---|
| 1127 |
|
|---|
| 1128 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm;
|
|---|
| 1129 | mso-layout-grid-align:none;text-autospace:none'><span class=GramE><b><span
|
|---|
| 1130 | lang=EN-GB style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'>left</span></b></span><b><span
|
|---|
| 1131 | lang=EN-GB style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'>
|
|---|
| 1132 | plot :</span></b><span lang=EN-GB style='font-family:Arial;color:#CCFFCC;
|
|---|
| 1133 | mso-ansi-language:EN-GB'> <i>nucleus <span class=SpellE>voxel</span> intensity
|
|---|
| 1134 | (0-255) distribution, two density zones have been isolated in the simulation</i><o:p></o:p></span></p>
|
|---|
| 1135 |
|
|---|
| 1136 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm;
|
|---|
| 1137 | mso-layout-grid-align:none;text-autospace:none'><span class=GramE><b><span
|
|---|
| 1138 | lang=EN-GB style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'>middle</span></b></span><b><span
|
|---|
| 1139 | lang=EN-GB style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'>
|
|---|
| 1140 | left plot :</span></b><span lang=EN-GB style='font-family:Arial;color:#CCFFCC;
|
|---|
| 1141 | mso-ansi-language:EN-GB'> <i>alpha dose deposit in nucleus</i><o:p></o:p></span></p>
|
|---|
| 1142 |
|
|---|
| 1143 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm;
|
|---|
| 1144 | mso-layout-grid-align:none;text-autospace:none'><span class=GramE><b><span
|
|---|
| 1145 | lang=EN-GB style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'>middle</span></b></span><b><span
|
|---|
| 1146 | lang=EN-GB style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'>
|
|---|
| 1147 | right plot :</span></b><span lang=EN-GB style='font-family:Arial;color:#CCFFCC;
|
|---|
| 1148 | mso-ansi-language:EN-GB'> <i>nucleus <span class=SpellE>voxel</span> intensity
|
|---|
| 1149 | projected on cell transverse section<o:p></o:p></i></span></p>
|
|---|
| 1150 |
|
|---|
| 1151 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm;
|
|---|
| 1152 | mso-layout-grid-align:none;text-autospace:none'><span class=GramE><b><span
|
|---|
| 1153 | lang=EN-GB style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'>right</span></b></span><b><span
|
|---|
| 1154 | lang=EN-GB style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'>
|
|---|
| 1155 | plot :</span></b><i><span lang=EN-GB style='font-family:Arial;color:#CCFFCC;
|
|---|
| 1156 | mso-ansi-language:EN-GB'> beam transverse (X) position distribution on target.
|
|---|
| 1157 | The sigma of the Gaussian fit is compatible with the measured experimental
|
|---|
| 1158 | value.</span></i><span lang=EN-GB style='font-family:Arial;color:#CCFFCC;
|
|---|
| 1159 | mso-ansi-language:EN-GB'><o:p></o:p></span></p>
|
|---|
| 1160 |
|
|---|
| 1161 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm;
|
|---|
| 1162 | mso-layout-grid-align:none;text-autospace:none'><b><span lang=EN-GB
|
|---|
| 1163 | style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'><o:p> </o:p></span></b></p>
|
|---|
| 1164 |
|
|---|
| 1165 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm;
|
|---|
| 1166 | mso-layout-grid-align:none;text-autospace:none'><b><span lang=EN-GB
|
|---|
| 1167 | style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'>MIDDLE row <o:p></o:p></span></b></p>
|
|---|
| 1168 |
|
|---|
| 1169 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm;
|
|---|
| 1170 | mso-layout-grid-align:none;text-autospace:none'><span class=GramE><b><span
|
|---|
| 1171 | lang=EN-GB style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'>left</span></b></span><b><span
|
|---|
| 1172 | lang=EN-GB style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'>
|
|---|
| 1173 | plot :</span></b><span lang=EN-GB style='font-family:Arial;color:#CCFFCC;
|
|---|
| 1174 | mso-ansi-language:EN-GB'> <i>cytoplasm <span class=SpellE>voxel</span>
|
|---|
| 1175 | intensity (0-255) distribution, two density zones have been isolated (one for pure
|
|---|
| 1176 | cytoplasm in red, the other for nucleoli in yellow)</i><o:p></o:p></span></p>
|
|---|
| 1177 |
|
|---|
| 1178 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm;
|
|---|
| 1179 | mso-layout-grid-align:none;text-autospace:none'><span class=GramE><b><span
|
|---|
| 1180 | lang=EN-GB style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'>middle</span></b></span><b><span
|
|---|
| 1181 | lang=EN-GB style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'>
|
|---|
| 1182 | left plot :</span></b><span lang=EN-GB style='font-family:Arial;color:#CCFFCC;
|
|---|
| 1183 | mso-ansi-language:EN-GB'> <i>alpha dose deposit in cytoplasm<o:p></o:p></i></span></p>
|
|---|
| 1184 |
|
|---|
| 1185 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm;
|
|---|
| 1186 | mso-layout-grid-align:none;text-autospace:none'><span class=GramE><b><span
|
|---|
| 1187 | lang=EN-GB style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'>middle</span></b></span><b><span
|
|---|
| 1188 | lang=EN-GB style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'>
|
|---|
| 1189 | right plot :</span></b><span lang=EN-GB style='font-family:Arial;color:#CCFFCC;
|
|---|
| 1190 | mso-ansi-language:EN-GB'> <i>cytoplasm <span class=SpellE>voxel</span>
|
|---|
| 1191 | intensity projected on cell transverse section<o:p></o:p></i></span></p>
|
|---|
| 1192 |
|
|---|
| 1193 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm;
|
|---|
| 1194 | mso-layout-grid-align:none;text-autospace:none'><span class=GramE><b><span
|
|---|
| 1195 | lang=EN-GB style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'>right</span></b></span><b><span
|
|---|
| 1196 | lang=EN-GB style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'>
|
|---|
| 1197 | plot :</span></b><i><span lang=EN-GB style='font-family:Arial;color:#CCFFCC;
|
|---|
| 1198 | mso-ansi-language:EN-GB'> beam transverse (Y) position distribution on target.
|
|---|
| 1199 | The sigma of the Gaussian fit is compatible with the measured experimental
|
|---|
| 1200 | value.</span></i><span lang=EN-GB style='font-family:Arial;color:#CCFFCC;
|
|---|
| 1201 | mso-ansi-language:EN-GB'><o:p></o:p></span></p>
|
|---|
| 1202 |
|
|---|
| 1203 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm;
|
|---|
| 1204 | mso-layout-grid-align:none;text-autospace:none'><b><span lang=EN-GB
|
|---|
| 1205 | style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'><o:p> </o:p></span></b></p>
|
|---|
| 1206 |
|
|---|
| 1207 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm;
|
|---|
| 1208 | mso-layout-grid-align:none;text-autospace:none'><b><span lang=EN-GB
|
|---|
| 1209 | style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'>BOTTOM row <o:p></o:p></span></b></p>
|
|---|
| 1210 |
|
|---|
| 1211 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm;
|
|---|
| 1212 | mso-layout-grid-align:none;text-autospace:none'><span class=GramE><b><span
|
|---|
| 1213 | lang=EN-GB style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'>left</span></b></span><b><span
|
|---|
| 1214 | lang=EN-GB style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'>
|
|---|
| 1215 | plot :</span></b><span lang=EN-GB style='font-family:Arial;color:#CCFFCC;
|
|---|
| 1216 | mso-ansi-language:EN-GB'> <i>beam stopping power <span class=SpellE>dE/dx</span>
|
|---|
| 1217 | distribution at cell entrance<o:p></o:p></i></span></p>
|
|---|
| 1218 |
|
|---|
| 1219 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm;
|
|---|
| 1220 | mso-layout-grid-align:none;text-autospace:none'><span class=GramE><b><span
|
|---|
| 1221 | lang=EN-GB style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'>middle</span></b></span><b><span
|
|---|
| 1222 | lang=EN-GB style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'>
|
|---|
| 1223 | left plot :</span></b><span lang=EN-GB style='font-family:Arial;color:#CCFFCC;
|
|---|
| 1224 | mso-ansi-language:EN-GB'> <i>3D distribution of alpha particle range in cell or
|
|---|
| 1225 | medium<o:p></o:p></i></span></p>
|
|---|
| 1226 |
|
|---|
| 1227 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm;
|
|---|
| 1228 | mso-layout-grid-align:none;text-autospace:none'><span class=GramE><b><span
|
|---|
| 1229 | lang=EN-GB style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'>middle</span></b></span><b><span
|
|---|
| 1230 | lang=EN-GB style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'>
|
|---|
| 1231 | right plot :</span></b><span lang=EN-GB style='font-family:Arial;color:#CCFFCC;
|
|---|
| 1232 | mso-ansi-language:EN-GB'> <i>projected mean energy deposit per <span
|
|---|
| 1233 | class=SpellE>voxel</span> (transverse, z axis is in <span class=SpellE>eV</span>)<o:p></o:p></i></span></p>
|
|---|
| 1234 |
|
|---|
| 1235 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm;
|
|---|
| 1236 | mso-layout-grid-align:none;text-autospace:none'><span class=GramE><b><span
|
|---|
| 1237 | lang=EN-GB style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'>right</span></b></span><b><span
|
|---|
| 1238 | lang=EN-GB style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'>
|
|---|
| 1239 | plot : </span></b><i><span lang=EN-GB style='font-family:Arial;color:#CCFFCC;
|
|---|
| 1240 | mso-ansi-language:EN-GB'>projected mean energy deposit per <span class=SpellE>voxel</span>
|
|---|
| 1241 | (longitudinal, z axis is in <span class=SpellE>eV</span>).</span></i><span
|
|---|
| 1242 | lang=EN-GB style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'><o:p></o:p></span></p>
|
|---|
| 1243 |
|
|---|
| 1244 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm;
|
|---|
| 1245 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB
|
|---|
| 1246 | style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'><o:p> </o:p></span></p>
|
|---|
| 1247 |
|
|---|
| 1248 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm;
|
|---|
| 1249 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB
|
|---|
| 1250 | style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'><o:p> </o:p></span></p>
|
|---|
| 1251 |
|
|---|
| 1252 | <p class=MsoNormal style='mso-layout-grid-align:none;text-autospace:none'><span
|
|---|
| 1253 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>The
|
|---|
| 1254 | simulation predicts that 95% of the incident alpha particles detected by the
|
|---|
| 1255 | gas detector are located within a circle of 10 µm in diameter on the target, in
|
|---|
| 1256 | nice agreement with experimental measurements performed on the CENBG setup.<o:p></o:p></span></p>
|
|---|
| 1257 |
|
|---|
| 1258 | <p class=MsoNormal align=center style='text-align:center;mso-layout-grid-align:
|
|---|
| 1259 | none;text-autospace:none'><span lang=EN-GB style='font-family:Arial;color:white;
|
|---|
| 1260 | mso-ansi-language:EN-GB'><o:p> </o:p></span></p>
|
|---|
| 1261 |
|
|---|
| 1262 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 1263 | mso-layout-grid-align:none;text-autospace:none'><b><span lang=EN-GB
|
|---|
| 1264 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></b></p>
|
|---|
| 1265 |
|
|---|
| 1266 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 1267 | mso-layout-grid-align:none;text-autospace:none'><b><span lang=EN-GB
|
|---|
| 1268 | style='font-family:Arial;color:#66CCFF;mso-ansi-language:EN-GB'>FUTURE<o:p></o:p></span></b></p>
|
|---|
| 1269 |
|
|---|
| 1270 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 1271 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB
|
|---|
| 1272 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p>
|
|---|
| 1273 |
|
|---|
| 1274 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 1275 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB
|
|---|
| 1276 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>Running this
|
|---|
| 1277 | example requires a large amount of memory and CPU time. Decrease of memory use
|
|---|
| 1278 | and acceleration of navigation could be investigated using nested
|
|---|
| 1279 | parameterization. Microdosimetry with other geometries like 3D tissues will be
|
|---|
| 1280 | investigated.<o:p></o:p></span></p>
|
|---|
| 1281 |
|
|---|
| 1282 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 1283 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB
|
|---|
| 1284 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p>
|
|---|
| 1285 |
|
|---|
| 1286 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 1287 | mso-layout-grid-align:none;text-autospace:none'><b><span lang=EN-GB
|
|---|
| 1288 | style='font-family:Arial;color:#66CCFF;mso-ansi-language:EN-GB'><o:p> </o:p></span></b></p>
|
|---|
| 1289 |
|
|---|
| 1290 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 1291 | mso-layout-grid-align:none;text-autospace:none'><b><span lang=EN-GB
|
|---|
| 1292 | style='font-family:Arial;color:#66CCFF;mso-ansi-language:EN-GB'>CONTACT<o:p></o:p></span></b></p>
|
|---|
| 1293 |
|
|---|
| 1294 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 1295 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB
|
|---|
| 1296 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p>
|
|---|
| 1297 |
|
|---|
| 1298 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 1299 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB
|
|---|
| 1300 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>Should you have
|
|---|
| 1301 | any enquiry, please do not hesitate to contact the corresponding <span
|
|---|
| 1302 | class=GramE>author :</span> </span><span lang=EN-GB style='font-family:Arial;
|
|---|
| 1303 | color:aqua;mso-ansi-language:EN-GB'><a href="mailto:incerti@cenbg.in2p3.fr"><span
|
|---|
| 1304 | style='color:aqua;text-decoration:none;text-underline:none'>incerti@cenbg.in2p3.fr</span></a>
|
|---|
| 1305 | <o:p></o:p></span></p>
|
|---|
| 1306 |
|
|---|
| 1307 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph;
|
|---|
| 1308 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB
|
|---|
| 1309 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p>
|
|---|
| 1310 |
|
|---|
| 1311 | <p class=MsoNormal align=right style='text-align:right;mso-layout-grid-align:
|
|---|
| 1312 | none;text-autospace:none'><span lang=EN-GB style='font-family:Arial;color:white;
|
|---|
| 1313 | mso-ansi-language:EN-GB'>Last modified by </span><st1:place><span lang=EN-GB
|
|---|
| 1314 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>S. Incerti</span></st1:place><span
|
|---|
| 1315 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>, <span
|
|---|
| 1316 | style='mso-field-code:" DATE \\\@ \0022dd\/MM\/yyyy\0022 "'><span
|
|---|
| 1317 | style='mso-no-proof:yes'>27/02/2007</span></span><o:p></o:p></span></p>
|
|---|
| 1318 |
|
|---|
| 1319 | </div>
|
|---|
| 1320 |
|
|---|
| 1321 | </body>
|
|---|
| 1322 |
|
|---|
| 1323 | </html>
|
|---|
