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171 | |
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172 | <p class=MsoNormal align=center style='text-align:center'><b><span lang=EN-GB |
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173 | style='font-size:20.0pt;font-family:Arial;color:#00CCFF;mso-ansi-language:EN-GB'>Geant4 |
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174 | <span class=SpellE>Microbeam</span> Advanced Example<o:p></o:p></span></b></p> |
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175 | |
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176 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph'><span |
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177 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p> |
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178 | |
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179 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph'><span |
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180 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p> |
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181 | |
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182 | <p class=MsoNormal align=center style='text-align:center'><b><span lang=EN-GB |
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183 | style='font-family:Arial;color:#FFCC99;mso-ansi-language:EN-GB'>Interface |
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184 | Physics Biology group<o:p></o:p></span></b></p> |
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185 | |
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186 | <p class=MsoNormal align=center style='text-align:center'><span class=GramE><span |
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187 | style='font-family:Arial;color:#FFCC99'>( <b>S</b></span></span><b><span |
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188 | style='font-family:Arial;color:#FFCC99'>. Incerti</span></b><span |
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189 | style='font-family:Arial;color:#FFCC99'>*, O. <span class=SpellE>Boissonnade</span>, |
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190 | C. <span class=SpellE>Habchi</span>, <span class=SpellE>Ph</span>. <span |
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191 | class=SpellE>Moretto</span>, D. T. <span class=SpellE>Nguyen</span>, T. <span |
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192 | class=SpellE>Pouthier</span>, H. <span class=SpellE>Seznec</span>, Q. Zhang )<o:p></o:p></span></p> |
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193 | |
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194 | <p class=MsoNormal align=center style='text-align:center;mso-layout-grid-align: |
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195 | none;text-autospace:none'><span style='font-family:Arial;color:#FFCC99'><o:p> </o:p></span></p> |
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196 | |
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197 | <p class=MsoNormal align=center style='text-align:center;mso-layout-grid-align: |
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198 | none;text-autospace:none'><b><span style='font-family:Arial;color:#FFCC99'>Centre |
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199 | dEtudes Nucléaires de <span class=SpellE>Bordeaux-Gradignan</span> (CENBG)<o:p></o:p></span></b></p> |
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200 | |
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201 | <p class=MsoNormal align=center style='text-align:center;mso-layout-grid-align: |
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202 | none;text-autospace:none'><b><span lang=EN-GB style='font-family:Arial; |
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203 | color:#FFCC99;mso-ansi-language:EN-GB'>IN2P3 / CNRS / </span></b><st1:City><st1:place><b><span |
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204 | lang=EN-GB style='font-family:Arial;color:#FFCC99;mso-ansi-language:EN-GB'>Bordeaux</span></b></st1:place></st1:City><b><span |
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205 | lang=EN-GB style='font-family:Arial;color:#FFCC99;mso-ansi-language:EN-GB'> 1 |
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206 | University<o:p></o:p></span></b></p> |
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207 | |
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208 | <p class=MsoNormal align=center style='text-align:center;mso-layout-grid-align: |
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209 | none;text-autospace:none'><b><span lang=EN-GB style='font-family:Arial; |
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210 | color:#FFCC99;mso-ansi-language:EN-GB'>33175 <span class=SpellE>Gradignan</span><o:p></o:p></span></b></p> |
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211 | |
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212 | <p class=MsoNormal align=center style='text-align:center;mso-layout-grid-align: |
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213 | none;text-autospace:none'><st1:country-region><st1:place><b><span lang=EN-GB |
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214 | style='font-family:Arial;color:#FFCC99;mso-ansi-language:EN-GB'>France</span></b></st1:place></st1:country-region><b><span |
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215 | lang=EN-GB style='font-family:Arial;color:#FFCC99;mso-ansi-language:EN-GB'><o:p></o:p></span></b></p> |
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216 | |
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217 | <p class=MsoNormal align=center style='text-align:center;mso-layout-grid-align: |
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218 | none;text-autospace:none'><span lang=EN-GB style='font-family:Arial;color:#FFCC99; |
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219 | mso-ansi-language:EN-GB'><o:p> </o:p></span></p> |
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220 | |
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221 | <p class=MsoNormal align=center style='text-align:center;mso-layout-grid-align: |
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222 | none;text-autospace:none'><span lang=EN-GB style='font-family:Arial;color:#FFCC99; |
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223 | mso-ansi-language:EN-GB'>* <span class=GramE>corresponding</span> author e-mail |
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224 | : </span><span style='font-family:Arial;color:aqua'><a |
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225 | href="mailto:incerti@cenbg.in2p3.fr"><span lang=EN-GB style='color:aqua; |
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226 | mso-ansi-language:EN-GB;text-decoration:none;text-underline:none'>incerti@cenbg.in2p3.fr</span></a></span><span |
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227 | style='font-family:Arial;color:aqua;mso-ansi-language:EN-GB'> <span lang=EN-GB><o:p></o:p></span></span></p> |
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228 | |
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229 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
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231 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p> |
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232 | |
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233 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
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234 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB |
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236 | style='mso-spacerun:yes'> |
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237 | </span><o:p></o:p></span></p> |
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238 | |
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239 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
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240 | mso-layout-grid-align:none;text-autospace:none'><b><span lang=EN-GB |
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241 | style='font-family:Arial;color:#66CCFF;mso-ansi-language:EN-GB'>INTRODUCTION<o:p></o:p></span></b></p> |
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242 | |
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243 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
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244 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB |
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245 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p> |
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246 | |
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247 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
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248 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB |
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249 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>The <span |
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250 | class=SpellE>microbeam</span> example simulates the <span class=SpellE>microbeam</span> |
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251 | cellular irradiation beam line installed on the AIFIRA electrostatic |
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252 | accelerator facility located at CENBG, </span><st1:place><st1:City><span |
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253 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>Bordeaux-<span |
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254 | class=SpellE>Gradignan</span></span></st1:City><span lang=EN-GB |
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255 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>, </span><st1:country-region><span |
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256 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>France</span></st1:country-region></st1:place><span |
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257 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>. This |
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258 | setup is mainly used to investigate the effects of low dose irradiation on |
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259 | living cells. The <span class=SpellE>microbeam</span> line allows </span><b><span |
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260 | lang=EN-GB style='font-family:Arial;color:yellow;mso-ansi-language:EN-GB'>irradiation |
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261 | of</span></b><span lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language: |
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262 | EN-GB'> </span><b><span lang=EN-GB style='font-family:Arial;color:yellow; |
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263 | mso-ansi-language:EN-GB'>individual biological living cells</span></b><span |
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264 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'> in |
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265 | culture medium in single ion mode, with an </span><b><span lang=EN-GB |
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266 | style='font-family:Arial;color:yellow;mso-ansi-language:EN-GB'>exact control of |
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267 | the delivered dose to a particular cell</span></b><span lang=EN-GB |
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268 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'> among the cell |
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269 | population. This Geant4 example simulates the <span class=SpellE>microbeam</span> |
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270 | line in a configuration of irradiation with 3 MeV incident alpha particles and |
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271 | allows the calculation of the dose deposited by the incident particles in the |
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272 | cell cytoplasm and in the cell nucleus, which are inaccessible by experimental |
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273 | measurements. For the first time in </span><st1:place><span lang=EN-GB |
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274 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>Monte Carlo</span></st1:place><span |
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275 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'> <span |
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276 | class=SpellE>microdosimetry</span>, the simulation includes a realistic cell |
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277 | phantom obtained from <span class=SpellE>confocal</span> microscopy. <o:p></o:p></span></p> |
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278 | |
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279 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
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281 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p> |
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282 | |
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283 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
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284 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB |
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285 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>For more |
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286 | information on this irradiation facility, please <span class=GramE>visit :</span><o:p></o:p></span></p> |
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287 | |
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293 | mso-layout-grid-align:none;text-autospace:none'><b><span lang=EN-GB |
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294 | style='font-family:Arial;color:aqua;mso-ansi-language:EN-GB'><a |
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295 | href="http://www.cenbg.in2p3.fr/"><span style='color:aqua;text-decoration:none; |
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296 | text-underline:none'>http://www.cenbg.in2p3.fr</span></a><o:p></o:p></span></b></p> |
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328 | </v:shapetype><v:shape id="_x0000_i1025" type="#_x0000_t75" style='width:408.75pt; |
---|
329 | height:279pt;mso-position-vertical:absolute' o:ole="" o:allowoverlap="f" |
---|
330 | fillcolor="#6cf"> |
---|
331 | <v:imagedata src="microbeam_fichiers/image001.png" o:title="" croptop="1077f" |
---|
332 | cropright="1886f"/> |
---|
333 | </v:shape><![endif]--><![if !vml]><img border=0 width=545 height=372 |
---|
334 | src="microbeam_fichiers/image002.gif" v:shapes="_x0000_i1025"><![endif]><!--[if gte mso 9]><xml> |
---|
335 | <o:OLEObject Type="Embed" ProgID="MSPhotoEd.3" ShapeID="_x0000_i1025" |
---|
336 | DrawAspect="Content" ObjectID="_1234075214"> |
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337 | </o:OLEObject> |
---|
338 | </xml><![endif]--><o:p></o:p></span></p> |
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339 | |
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340 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm; |
---|
341 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB |
---|
342 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p> |
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343 | |
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344 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm; |
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345 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB |
---|
346 | style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'>Schematic view |
---|
347 | of the CENBG five AIFIRA beam <span class=GramE>lines :</span> <br> |
---|
348 | the <span class=SpellE>microbeam</span> line is located at 10° from the main |
---|
349 | exit of the switching magnet (© CENBG)<o:p></o:p></span></p> |
---|
350 | |
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351 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm; |
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352 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB |
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353 | style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'><o:p> </o:p></span></p> |
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354 | |
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355 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm; |
---|
356 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB |
---|
357 | style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'><o:p> </o:p></span></p> |
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358 | |
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359 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm; |
---|
360 | mso-layout-grid-align:none;text-autospace:none'><!--[if gte vml 1]><v:shape |
---|
361 | id="_x0000_i1026" type="#_x0000_t75" style='width:274.5pt;height:418.5pt'> |
---|
362 | <v:imagedata src="microbeam_fichiers/image003.png" o:title=""/> |
---|
363 | </v:shape><![endif]--><![if !vml]><img border=0 width=366 height=558 |
---|
364 | src="microbeam_fichiers/image004.jpg" v:shapes="_x0000_i1026"><![endif]></p> |
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365 | |
---|
366 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm; |
---|
367 | mso-layout-grid-align:none;text-autospace:none'><o:p> </o:p></p> |
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368 | |
---|
369 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm; |
---|
370 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB |
---|
371 | style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'>View of the |
---|
372 | CENBG <span class=SpellE>microbeam</span> line (© CENBG)</span><span |
---|
373 | lang=EN-GB style='mso-ansi-language:EN-GB'><o:p></o:p></span></p> |
---|
374 | |
---|
375 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
376 | tab-stops:right 16.0cm;mso-layout-grid-align:none;text-autospace:none'><span |
---|
377 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p> |
---|
378 | |
---|
379 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
380 | tab-stops:right 16.0cm;mso-layout-grid-align:none;text-autospace:none'><span |
---|
381 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p> |
---|
382 | |
---|
383 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
384 | mso-layout-grid-align:none;text-autospace:none'><b><span lang=EN-GB |
---|
385 | style='font-family:Arial;color:#66CCFF;mso-ansi-language:EN-GB'>SIMULATED SETUP<o:p></o:p></span></b></p> |
---|
386 | |
---|
387 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
388 | tab-stops:right 16.0cm;mso-layout-grid-align:none;text-autospace:none'><span |
---|
389 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p> |
---|
390 | |
---|
391 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
392 | tab-stops:right 16.0cm;mso-layout-grid-align:none;text-autospace:none'><span |
---|
393 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>The beam |
---|
394 | is emitted just before the 10° switching magnet taking into account |
---|
395 | experimental beam parameters <span class=GramE>measurements ;</span> the main |
---|
396 | elements simulated are :<o:p></o:p></span></p> |
---|
397 | |
---|
398 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
399 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB |
---|
400 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p> |
---|
401 | |
---|
402 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
403 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB |
---|
404 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>1. A </span><b><span |
---|
405 | lang=EN-GB style='font-family:Arial;color:yellow;mso-ansi-language:EN-GB'>switching |
---|
406 | dipole magnet</span></b><span lang=EN-GB style='font-family:Arial;color:white; |
---|
407 | mso-ansi-language:EN-GB'> with fringing field, to deflect by 10° the 3 MeV |
---|
408 | alpha beam generated by the electrostatic accelerator into the <span |
---|
409 | class=SpellE>microbeam</span> line, oriented at 10 degrees from the main beam |
---|
410 | direction;<o:p></o:p></span></p> |
---|
411 | |
---|
412 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
413 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB |
---|
414 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p> |
---|
415 | |
---|
416 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
417 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB |
---|
418 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>2. A </span><b><span |
---|
419 | lang=EN-GB style='font-family:Arial;color:yellow;mso-ansi-language:EN-GB'>circular |
---|
420 | object collimator</span></b><span lang=EN-GB style='font-family:Arial; |
---|
421 | color:white;mso-ansi-language:EN-GB'>, defining the incident beam size at the <span |
---|
422 | class=SpellE>microbeam</span> line entrance; the collimator has been simulated |
---|
423 | from realistic electron microscopy images;<o:p></o:p></span></p> |
---|
424 | |
---|
425 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
426 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB |
---|
427 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p> |
---|
428 | |
---|
429 | <p class=MsoNormal align=center style='text-align:center;mso-layout-grid-align: |
---|
430 | none;text-autospace:none'><!--[if gte vml 1]><v:shape id="_x0000_i1027" type="#_x0000_t75" |
---|
431 | style='width:182.25pt;height:200.25pt;mso-position-horizontal:absolute; |
---|
432 | mso-position-horizontal-relative:text;mso-position-vertical:absolute; |
---|
433 | mso-position-vertical-relative:text' o:allowoverlap="f"> |
---|
434 | <v:imagedata src="microbeam_fichiers/image015.emz" o:title=""/> |
---|
435 | </v:shape><![endif]--><![if !vml]><img border=0 width=243 height=267 |
---|
436 | src="microbeam_fichiers/image006.gif" v:shapes="_x0000_i1027"><![endif]></p> |
---|
437 | |
---|
438 | <p class=MsoNormal align=center style='text-align:center;mso-layout-grid-align: |
---|
439 | none;text-autospace:none'><o:p> </o:p></p> |
---|
440 | |
---|
441 | <p class=MsoNormal align=center style='text-align:center;mso-layout-grid-align: |
---|
442 | none;text-autospace:none'><span lang=EN-GB style='font-family:Arial;color:#CCFFCC; |
---|
443 | mso-ansi-language:EN-GB'>Collimator geometry implemented in Geant4 as embedded |
---|
444 | cones </span><span lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language: |
---|
445 | EN-GB'><o:p></o:p></span></p> |
---|
446 | |
---|
447 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
448 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB |
---|
449 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p> |
---|
450 | |
---|
451 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
452 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB |
---|
453 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p> |
---|
454 | |
---|
455 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
456 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB |
---|
457 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>3. A </span><b><span |
---|
458 | lang=EN-GB style='font-family:Arial;color:yellow;mso-ansi-language:EN-GB'>quadrupole |
---|
459 | based magnetic symmetric focusing system</span></b><span lang=EN-GB |
---|
460 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'> allowing equal |
---|
461 | transverse demagnifications of 10. Fringe fields are calculated from Enges |
---|
462 | model.<o:p></o:p></span></p> |
---|
463 | |
---|
464 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
465 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB |
---|
466 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p> |
---|
467 | |
---|
468 | <p class=MsoNormal align=center style='text-align:center;mso-layout-grid-align: |
---|
469 | none;text-autospace:none'><span lang=EN-GB style='font-family:Arial;color:white; |
---|
470 | mso-ansi-language:EN-GB'><!--[if gte vml 1]><v:shape id="_x0000_i1028" type="#_x0000_t75" |
---|
471 | style='width:457.5pt;height:235.5pt'> |
---|
472 | <v:imagedata src="microbeam_fichiers/image007.jpg" o:title="beam" cropleft="1038f" |
---|
473 | chromakey="white" gain="45875f" blacklevel=".5" grayscale="t" bilevel="t"/> |
---|
474 | </v:shape><![endif]--><![if !vml]><img border=0 width=610 height=314 |
---|
475 | src="microbeam_fichiers/image008.gif" v:shapes="_x0000_i1028"><![endif]><o:p></o:p></span></p> |
---|
476 | |
---|
477 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm; |
---|
478 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB |
---|
479 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p> |
---|
480 | |
---|
481 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm; |
---|
482 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB |
---|
483 | style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'>Geant4 fine |
---|
484 | ray-tracing of beam profile inside the focusing quadruplet in both horizontal |
---|
485 | and transverse planes, showing the beam focus point.<o:p></o:p></span></p> |
---|
486 | |
---|
487 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm; |
---|
488 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB |
---|
489 | style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'><o:p> </o:p></span></p> |
---|
490 | |
---|
491 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
492 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB |
---|
493 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p> |
---|
494 | |
---|
495 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
496 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB |
---|
497 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>4. A dedicated </span><b><span |
---|
498 | lang=EN-GB style='font-family:Arial;color:yellow;mso-ansi-language:EN-GB'>cellular |
---|
499 | irradiation chamber setup</span></b><span lang=EN-GB style='font-family:Arial; |
---|
500 | color:white;mso-ansi-language:EN-GB'>, taking into account all the elements |
---|
501 | encountered by the incident beam (diaphragm, gas detector, <span class=SpellE>isobutane</span>, |
---|
502 | beam extraction window, air, culture foil, culture medium, cell dish
) ;<o:p></o:p></span></p> |
---|
503 | |
---|
504 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
505 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB |
---|
506 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p> |
---|
507 | |
---|
508 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
509 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB |
---|
510 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>5. A set of |
---|
511 | horizontal and vertical </span><b><span lang=EN-GB style='font-family:Arial; |
---|
512 | color:yellow;mso-ansi-language:EN-GB'>electrostatic deflecting plates</span></b><span |
---|
513 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'> which |
---|
514 | can be turned on or off to deflect the beam on target; <o:p></o:p></span></p> |
---|
515 | |
---|
516 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
517 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB |
---|
518 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p> |
---|
519 | |
---|
520 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
521 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB |
---|
522 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>6. A </span><b><span |
---|
523 | lang=EN-GB style='font-family:Arial;color:yellow;mso-ansi-language:EN-GB'>realistic |
---|
524 | human <span class=SpellE>keratinocyte</span> <span class=SpellE>voxellized</span> |
---|
525 | cell</span></b><span lang=EN-GB style='font-family:Arial;color:white; |
---|
526 | mso-ansi-language:EN-GB'> observed from confocal microscopy and taking into |
---|
527 | account realistic nucleus and cytoplasm chemical compositions. The phantom uses |
---|
528 | the G4PVParameterised class.<o:p></o:p></span></p> |
---|
529 | |
---|
530 | <p class=MsoNormal align=center style='text-align:center;mso-layout-grid-align: |
---|
531 | none;text-autospace:none'><span lang=EN-GB style='mso-ansi-language:EN-GB'><o:p> </o:p></span></p> |
---|
532 | |
---|
533 | <p class=MsoNormal align=center style='text-align:center;mso-layout-grid-align: |
---|
534 | none;text-autospace:none'><span lang=EN-GB style='mso-ansi-language:EN-GB'><o:p> </o:p></span></p> |
---|
535 | |
---|
536 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm; |
---|
537 | mso-layout-grid-align:none;text-autospace:none'><!--[if gte vml 1]><v:shape |
---|
538 | id="_x0000_i1029" type="#_x0000_t75" style='width:195.75pt;height:267.75pt'> |
---|
539 | <v:imagedata src="microbeam_fichiers/image009.jpg" o:title="24h" croptop="10627f" |
---|
540 | cropbottom="7872f" cropleft="14295f" cropright="12755f"/> |
---|
541 | </v:shape><![endif]--><![if !vml]><img border=0 width=261 height=357 |
---|
542 | src="microbeam_fichiers/image010.jpg" v:shapes="_x0000_i1029"><![endif]><span |
---|
543 | lang=EN-GB style='mso-ansi-language:EN-GB'><o:p></o:p></span></p> |
---|
544 | |
---|
545 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm; |
---|
546 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB |
---|
547 | style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'><o:p> </o:p></span></p> |
---|
548 | |
---|
549 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm; |
---|
550 | mso-layout-grid-align:none;text-autospace:none'><span class=SpellE><span |
---|
551 | lang=EN-GB style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'>Confocal</span></span><span |
---|
552 | lang=EN-GB style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'> |
---|
553 | microscopy image of a HaCat cell showing the cytoplasm (red) and the nucleus |
---|
554 | (purple) <br> |
---|
555 | © CENBG<o:p></o:p></span></p> |
---|
556 | |
---|
557 | <p class=MsoNormal align=center style='text-align:center;mso-layout-grid-align: |
---|
558 | none;text-autospace:none'><span lang=EN-GB style='mso-ansi-language:EN-GB'><o:p> </o:p></span></p> |
---|
559 | |
---|
560 | <p class=MsoNormal align=center style='text-align:center;mso-layout-grid-align: |
---|
561 | none;text-autospace:none'><span lang=EN-GB style='mso-ansi-language:EN-GB'><span |
---|
562 | style='mso-tab-count:2'> </span></span><!--[if gte vml 1]><v:shape |
---|
563 | id="_x0000_i1030" type="#_x0000_t75" style='width:323.25pt;height:321.75pt'> |
---|
564 | <v:imagedata src="microbeam_fichiers/image011.png" o:title=""/> |
---|
565 | </v:shape><![endif]--><![if !vml]><img border=0 width=431 height=429 |
---|
566 | src="microbeam_fichiers/image012.jpg" v:shapes="_x0000_i1030"><![endif]><span |
---|
567 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p></o:p></span></p> |
---|
568 | |
---|
569 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
570 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB |
---|
571 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p> |
---|
572 | |
---|
573 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm; |
---|
574 | mso-layout-grid-align:none;text-autospace:none'><span class=GramE><span |
---|
575 | lang=EN-GB style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'>Corresponding |
---|
576 | Geant4 phantom showing four incident alpha particles penetrating the cell.</span></span><span |
---|
577 | lang=EN-GB style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'> <br> |
---|
578 | The phantom is made of voxels with a size of 489 nm (X) x 489 nm (Y) x 163 nm |
---|
579 | (Z). <br> |
---|
580 | Approximately 4x10<sup>4</sup> <span class=SpellE>voxels</span> are shown.<o:p></o:p></span></p> |
---|
581 | |
---|
582 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
583 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB |
---|
584 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p> |
---|
585 | |
---|
586 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
587 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB |
---|
588 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p> |
---|
589 | |
---|
590 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
591 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB |
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592 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p> |
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593 | |
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594 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
595 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB |
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596 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p> |
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597 | |
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598 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
599 | mso-layout-grid-align:none;text-autospace:none'><b><span lang=EN-GB |
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600 | style='font-family:Arial;color:#66CCFF;mso-ansi-language:EN-GB'>PHYSICS<o:p></o:p></span></b></p> |
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601 | |
---|
602 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
603 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB |
---|
604 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p> |
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605 | |
---|
606 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
607 | mso-layout-grid-align:none;text-autospace:none'><b><span lang=EN-GB |
---|
608 | style='font-family:Arial;color:yellow;mso-ansi-language:EN-GB'>Low energy |
---|
609 | electromagnetic</span></b><span lang=EN-GB style='font-family:Arial;color:white; |
---|
610 | mso-ansi-language:EN-GB'> processes (for alphas, electrons, photons) and </span><span |
---|
611 | class=SpellE><b><span lang=EN-GB style='font-family:Arial;color:yellow; |
---|
612 | mso-ansi-language:EN-GB'>hadronic</span></b></span><b><span lang=EN-GB |
---|
613 | style='font-family:Arial;color:yellow;mso-ansi-language:EN-GB'> elastic and |
---|
614 | inelastic scattering</span></b><span lang=EN-GB style='font-family:Arial; |
---|
615 | color:white;mso-ansi-language:EN-GB'> for alphas are activated by default. Low |
---|
616 | energy electromagnetic electronic and nuclear stopping <span class=GramE>power |
---|
617 | are</span> computed from ICRU tables.<o:p></o:p></span></p> |
---|
618 | |
---|
619 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
620 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB |
---|
621 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><span |
---|
622 | style='mso-tab-count:1'> </span><o:p></o:p></span></p> |
---|
623 | |
---|
624 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
625 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB |
---|
626 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p> |
---|
627 | |
---|
628 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
629 | mso-layout-grid-align:none;text-autospace:none'><b><span lang=EN-GB |
---|
630 | style='font-family:Arial;color:#66CCFF;mso-ansi-language:EN-GB'>CODE DESIGN<o:p></o:p></span></b></p> |
---|
631 | |
---|
632 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
633 | mso-layout-grid-align:none;text-autospace:none'><b><span lang=EN-GB |
---|
634 | style='font-family:Arial;color:#66CCFF;mso-ansi-language:EN-GB'><o:p> </o:p></span></b></p> |
---|
635 | |
---|
636 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
637 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB |
---|
638 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>The <span |
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639 | class=SpellE>Microbeam</span> code design obtained from the Rational Rose |
---|
640 | software is shown below.<o:p></o:p></span></p> |
---|
641 | |
---|
642 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
643 | mso-layout-grid-align:none;text-autospace:none'><b><span lang=EN-GB |
---|
644 | style='font-family:Arial;color:#66CCFF;mso-ansi-language:EN-GB'><o:p> </o:p></span></b></p> |
---|
645 | |
---|
646 | <p class=MsoNormal align=center style='text-align:center;mso-layout-grid-align: |
---|
647 | none;text-autospace:none'><!--[if gte vml 1]><v:shape id="_x0000_i1031" type="#_x0000_t75" |
---|
648 | style='width:644.25pt;height:485.25pt;mso-position-horizontal-relative:text; |
---|
649 | mso-position-vertical-relative:text' o:allowoverlap="f"> |
---|
650 | <v:imagedata src="microbeam_fichiers/image016.emz" o:title=""/> |
---|
651 | </v:shape><![endif]--><![if !vml]><img border=0 width=859 height=647 |
---|
652 | src="microbeam_fichiers/image014.gif" v:shapes="_x0000_i1031"><![endif]><span |
---|
653 | lang=EN-GB style='mso-ansi-language:EN-GB'><o:p></o:p></span></p> |
---|
654 | |
---|
655 | <p class=MsoNormal align=center style='text-align:center;mso-layout-grid-align: |
---|
656 | none;text-autospace:none'><span lang=EN-GB style='mso-ansi-language:EN-GB'><o:p> </o:p></span></p> |
---|
657 | |
---|
658 | <p class=MsoNormal align=center style='text-align:center;mso-layout-grid-align: |
---|
659 | none;text-autospace:none'><span class=GramE><span lang=EN-GB style='font-family: |
---|
660 | Arial;color:#CCFFCC;mso-ansi-language:EN-GB'>Rational Rose class diagram of the |
---|
661 | <span class=SpellE>Microbeam</span> example.</span></span><span lang=EN-GB |
---|
662 | style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'> <o:p></o:p></span></p> |
---|
663 | |
---|
664 | <p class=MsoNormal align=center style='text-align:center;mso-layout-grid-align: |
---|
665 | none;text-autospace:none'><span lang=EN-GB style='font-family:Arial;color:#CCFFCC; |
---|
666 | mso-ansi-language:EN-GB'>Manager classes are filled with red and <span |
---|
667 | class=SpellE>Microbeam</span> classes are filled with sky blue.</span><b><span |
---|
668 | lang=EN-GB style='font-family:Arial;color:#66CCFF;mso-ansi-language:EN-GB'><o:p></o:p></span></b></p> |
---|
669 | |
---|
670 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
671 | mso-layout-grid-align:none;text-autospace:none'><b><span lang=EN-GB |
---|
672 | style='font-family:Arial;color:#66CCFF;mso-ansi-language:EN-GB'><o:p> </o:p></span></b></p> |
---|
673 | |
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674 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
675 | mso-layout-grid-align:none;text-autospace:none'><b><span lang=EN-GB |
---|
676 | style='font-family:Arial;color:#66CCFF;mso-ansi-language:EN-GB'><o:p> </o:p></span></b></p> |
---|
677 | |
---|
678 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
679 | mso-layout-grid-align:none;text-autospace:none'><b><span lang=EN-GB |
---|
680 | style='font-family:Arial;color:#66CCFF;mso-ansi-language:EN-GB'>SUGGESTED |
---|
681 | PAPERS ABOUT THIS SIMULATION AND ITS VALIDATION<o:p></o:p></span></b></p> |
---|
682 | |
---|
683 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
684 | mso-layout-grid-align:none;text-autospace:none'><b><span lang=EN-GB |
---|
685 | style='font-family:Arial;color:#66CCFF;mso-ansi-language:EN-GB'><o:p> </o:p></span></b></p> |
---|
686 | |
---|
687 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
688 | mso-layout-grid-align:none;text-autospace:none'><b><span lang=EN-GB |
---|
689 | style='font-family:Arial;color:yellow;mso-ansi-language:EN-GB'><span |
---|
690 | style='mso-tab-count:1'> </span>These papers can be accessed online |
---|
691 | at the SLAC-SPIRES online database by clicking </span></b><b><span lang=EN-GB |
---|
692 | style='font-family:Arial;color:red;mso-ansi-language:EN-GB'><a |
---|
693 | href="http://www.slac.stanford.edu/spires/find/hep/www?rawcmd=find+a+incerti&FORMAT=WWW&SEQUENCE="><span |
---|
694 | style='color:red'>here</span></a></span></b><b><span lang=EN-GB |
---|
695 | style='font-family:Arial;color:yellow;mso-ansi-language:EN-GB'> <o:p></o:p></span></b></p> |
---|
696 | |
---|
697 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
698 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB |
---|
699 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p> |
---|
700 | |
---|
701 | <p class=MsoNormal style='margin-left:35.4pt'><span lang=EN-GB |
---|
702 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>►</span><span |
---|
703 | lang=EN-GB style='font-family:Arial;color:#CC99FF;mso-ansi-language:EN-GB'> <b |
---|
704 | style='mso-bidi-font-weight:normal'><span style='text-transform:uppercase'>Monte |
---|
705 | Carlo microdosimetry for targeted irradiation of individual cells using a |
---|
706 | microbeam facility</span></b></span><span lang=EN-GB style='font-family:Arial; |
---|
707 | color:white;mso-ansi-language:EN-GB'> <o:p></o:p></span></p> |
---|
708 | |
---|
709 | <p class=MsoNormal style='margin-left:35.4pt'><span lang=EN-GB |
---|
710 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>By </span><st1:place><span |
---|
711 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>S. |
---|
712 | Incerti</span></st1:place><span lang=EN-GB style='font-family:Arial; |
---|
713 | color:white;mso-ansi-language:EN-GB'>, T. <span class=SpellE>Pouthier</span>, |
---|
714 | H. <span class=SpellE>Seznec</span>, Ph. </span><span lang=IT style='font-family: |
---|
715 | Arial;color:white;mso-ansi-language:IT'>Moretto, O. Boissonnade, T. M. H. |
---|
716 | Ha, F. Andersson, Ph. </span><span class=SpellE><span lang=EN-GB |
---|
717 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>Barberet</span></span><span |
---|
718 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>, C. <span |
---|
719 | class=SpellE>Habchi</span> and D. T. Nguyen <o:p></o:p></span></p> |
---|
720 | |
---|
721 | <p class=MsoNormal style='margin-left:35.4pt'><strong><span lang=EN-GB |
---|
722 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB;font-weight:normal; |
---|
723 | mso-bidi-font-weight:bold'>In preparation</span></strong><strong><span |
---|
724 | lang=EN-GB style='font-family:Arial;color:#FF9900;mso-ansi-language:EN-GB'> |
---|
725 | (2007)</span></strong><strong><span lang=EN-GB style='mso-ansi-language:EN-GB'><o:p></o:p></span></strong></p> |
---|
726 | |
---|
727 | <p class=MsoNormal><strong><span lang=EN-GB style='font-family:Arial; |
---|
728 | color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></strong></p> |
---|
729 | |
---|
730 | <p class=MsoNormal style='margin-left:35.4pt'><span lang=EN-GB |
---|
731 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>►</span><span |
---|
732 | lang=EN-GB style='font-family:Arial;color:#CC99FF;mso-ansi-language:EN-GB'> <b><span |
---|
733 | style='text-transform:uppercase'>Monte Carlo simulation of the CENBG microbeam |
---|
734 | and nanobeam lines with the Geant4 toolkit</span></b></span><span lang=EN-GB |
---|
735 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'> <br> |
---|
736 | By <span style='mso-bidi-font-weight:bold'>S</span>. <span style='mso-bidi-font-weight: |
---|
737 | bold'>Incerti</span>, Q. Zhang, F. <span class=SpellE>Andersson</span>, Ph. <span |
---|
738 | class=SpellE>Moretto</span>, G.W. Grime, M.J. Merchant, D.T. Nguyen, C. <span |
---|
739 | class=SpellE>Habchi</span>, T. <span class=SpellE>Pouthier</span> and H. <span |
---|
740 | class=SpellE>Seznec</span></span><span lang=EN-GB style='mso-ansi-language: |
---|
741 | EN-GB'><o:p></o:p></span></p> |
---|
742 | |
---|
743 | <p class=MsoNormal style='margin-left:35.4pt;text-align:justify;text-justify: |
---|
744 | inter-ideograph;mso-layout-grid-align:none;text-autospace:none'><span |
---|
745 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>In |
---|
746 | press in </span><span class=SpellE><b><span lang=EN-GB style='font-family:Arial; |
---|
747 | color:#FF9933;mso-ansi-language:EN-GB'>Nucl.Instrum.Meth.B</span></b></span><b><span |
---|
748 | lang=EN-GB style='font-family:Arial;color:#FF9933;mso-ansi-language:EN-GB'>, |
---|
749 | 2007<o:p></o:p></span></b></p> |
---|
750 | |
---|
751 | <p class=MsoNormal style='margin-left:35.4pt;text-align:justify;text-justify: |
---|
752 | inter-ideograph;mso-layout-grid-align:none;text-autospace:none'><span |
---|
753 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p> |
---|
754 | |
---|
755 | <p class=MsoNormal style='margin-left:35.4pt;mso-layout-grid-align:none; |
---|
756 | text-autospace:none'><span lang=EN-GB style='font-family:Arial;color:white; |
---|
757 | mso-ansi-language:EN-GB'>►</span><span lang=EN-GB style='font-family: |
---|
758 | Arial;color:#CC99FF;mso-ansi-language:EN-GB'> <b><span style='text-transform: |
---|
759 | uppercase'>A Comparison of cellular irradiation techniques with alpha particles |
---|
760 | using the Geant4 Monte Carlo simulation toolkit</span></b></span><span |
---|
761 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><br> |
---|
762 | By </span><span style='font-family:Arial;color:white'><a |
---|
763 | href="http://www.slac.stanford.edu/spires/find/wwwhepau/wwwscan?rawcmd=fin+%22Incerti%2C%20S%2E%22"><span |
---|
764 | lang=EN-GB style='color:white;mso-ansi-language:EN-GB;text-decoration:none; |
---|
765 | text-underline:none'>S. Incerti</span></a></span><span lang=EN-GB |
---|
766 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>, </span><span |
---|
767 | style='font-family:Arial;color:white'><a |
---|
768 | href="http://www.slac.stanford.edu/spires/find/wwwhepau/wwwscan?rawcmd=fin+%22Gault%2C%20N%2E%22"><span |
---|
769 | lang=EN-GB style='color:white;mso-ansi-language:EN-GB;text-decoration:none; |
---|
770 | text-underline:none'>N. <span class=SpellE>Gault</span></span></a></span><span |
---|
771 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>, </span><span |
---|
772 | style='font-family:Arial;color:white'><a |
---|
773 | href="http://www.slac.stanford.edu/spires/find/wwwhepau/wwwscan?rawcmd=fin+%22Habchi%2C%20C%2E%22"><span |
---|
774 | lang=EN-GB style='color:white;mso-ansi-language:EN-GB;text-decoration:none; |
---|
775 | text-underline:none'>C. <span class=SpellE>Habchi</span></span></a></span><span |
---|
776 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>, </span><span |
---|
777 | style='font-family:Arial;color:white'><a |
---|
778 | href="http://www.slac.stanford.edu/spires/find/wwwhepau/wwwscan?rawcmd=fin+%22Lefaix%2C%20J%2EL%2E%2E%22"><span |
---|
779 | lang=EN-GB style='color:white;mso-ansi-language:EN-GB;text-decoration:none; |
---|
780 | text-underline:none'>J.L.. <span class=SpellE>Lefaix</span></span></a></span><span |
---|
781 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>, </span><span |
---|
782 | style='font-family:Arial;color:white'><a |
---|
783 | href="http://www.slac.stanford.edu/spires/find/wwwhepau/wwwscan?rawcmd=fin+%22Moretto%2C%20Ph%2E%22"><span |
---|
784 | lang=EN-GB style='color:white;mso-ansi-language:EN-GB;text-decoration:none; |
---|
785 | text-underline:none'>Ph. <span class=SpellE>Moretto</span></span></a></span><span |
---|
786 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>, </span><span |
---|
787 | style='font-family:Arial;color:white'><a |
---|
788 | href="http://www.slac.stanford.edu/spires/find/wwwhepau/wwwscan?rawcmd=fin+%22Poncy%2C%20J%2EL%2E%2E%22"><span |
---|
789 | class=GramE><span lang=EN-GB style='color:white;mso-ansi-language:EN-GB; |
---|
790 | text-decoration:none;text-underline:none'>J.L..</span></span><span lang=EN-GB |
---|
791 | style='color:white;mso-ansi-language:EN-GB;text-decoration:none;text-underline: |
---|
792 | none'> <span class=SpellE>Poncy</span></span></a></span><span lang=EN-GB |
---|
793 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>, </span><span |
---|
794 | style='font-family:Arial;color:white'><a |
---|
795 | href="http://www.slac.stanford.edu/spires/find/wwwhepau/wwwscan?rawcmd=fin+%22Pouthier%2C%20T%2E%22"><span |
---|
796 | lang=EN-GB style='color:white;mso-ansi-language:EN-GB;text-decoration:none; |
---|
797 | text-underline:none'>T. <span class=SpellE>Pouthier</span></span></a></span><span |
---|
798 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>, </span><span |
---|
799 | style='font-family:Arial;color:white'><a |
---|
800 | href="http://www.slac.stanford.edu/spires/find/wwwhepau/wwwscan?rawcmd=fin+%22Seznec%2C%20H%2E%22"><span |
---|
801 | lang=EN-GB style='color:white;mso-ansi-language:EN-GB;text-decoration:none; |
---|
802 | text-underline:none'>H. <span class=SpellE>Seznec</span></span></a></span><span |
---|
803 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>. Dec |
---|
804 | 2006. 3pp<span class=GramE>.</span><br> |
---|
805 | Published in </span><b style='mso-bidi-font-weight:normal'><span lang=EN-GB |
---|
806 | style='font-family:Arial;color:#FF9900;mso-ansi-language:EN-GB'>Rad.Prot.Dos.,1-3,2006 |
---|
807 | (Micros 2005 special issue)</span></b><span lang=EN-GB style='font-family:Arial; |
---|
808 | color:white;mso-ansi-language:EN-GB'>.<o:p></o:p></span></p> |
---|
809 | |
---|
810 | <p class=MsoNormal style='margin-left:35.4pt;text-align:justify;text-justify: |
---|
811 | inter-ideograph;mso-layout-grid-align:none;text-autospace:none'><span |
---|
812 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p> |
---|
813 | |
---|
814 | <p class=MsoNormal style='margin-left:35.4pt;text-align:justify;text-justify: |
---|
815 | inter-ideograph;mso-layout-grid-align:none;text-autospace:none'><span |
---|
816 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>►</span><span |
---|
817 | lang=EN-GB style='font-family:Arial;color:#CC99FF;mso-ansi-language:EN-GB'> <b>GEANT4 |
---|
818 | SIMULATION OF THE NEW CENBG MICRO AND NANO PROBES FACILITY<o:p></o:p></b></span></p> |
---|
819 | |
---|
820 | <p class=MsoNormal style='margin-left:35.4pt;text-align:justify;text-justify: |
---|
821 | inter-ideograph;mso-layout-grid-align:none;text-autospace:none'><span |
---|
822 | class=GramE><span lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language: |
---|
823 | EN-GB'>By </span></span><st1:place><span class=GramE><span lang=EN-GB |
---|
824 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>S. Incerti</span></span></st1:place><span |
---|
825 | class=GramE><span lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language: |
---|
826 | EN-GB'>, C. Habchi, Ph. Moretto, J. Olivier and H. <span class=SpellE>Seznec</span>.</span></span><span |
---|
827 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'> May |
---|
828 | 2006. 5pp.<o:p></o:p></span></p> |
---|
829 | |
---|
830 | <p class=MsoNormal style='margin-left:35.4pt;text-align:justify;text-justify: |
---|
831 | inter-ideograph;mso-layout-grid-align:none;text-autospace:none'><span |
---|
832 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>Published |
---|
833 | in </span><b><span lang=EN-GB style='font-family:Arial;color:#FF9933; |
---|
834 | mso-ansi-language:EN-GB'>Nucl.Instrum.Meth.B249:738-742, 2006</span></b><b><span |
---|
835 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p></o:p></span></b></p> |
---|
836 | |
---|
837 | <p class=MsoNormal style='margin-left:35.4pt;text-align:justify;text-justify: |
---|
838 | inter-ideograph;mso-layout-grid-align:none;text-autospace:none'><span |
---|
839 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p> |
---|
840 | |
---|
841 | <p class=MsoNormal style='margin-left:35.4pt;mso-layout-grid-align:none; |
---|
842 | text-autospace:none'><span lang=EN-GB style='font-family:Arial;color:white; |
---|
843 | mso-ansi-language:EN-GB'>►</span><span lang=EN-GB style='font-family: |
---|
844 | Arial;color:#CC99FF;mso-ansi-language:EN-GB'> <span class=GramE><b><span |
---|
845 | style='text-transform:uppercase'>A</span></b></span><b><span style='text-transform: |
---|
846 | uppercase'> Comparison of ray-tracing software for the design of quadrupole |
---|
847 | microbeam systems</span></b><span style='text-transform:uppercase'><br> |
---|
848 | </span></span><span lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language: |
---|
849 | EN-GB'>By S. Incerti et al., <br> |
---|
850 | Published </span><span lang=EN-GB style='font-family:Arial;color:#FF9900; |
---|
851 | mso-ansi-language:EN-GB'>in <b>Nucl.Instrum.Meth.B231:76-85, 2005</b></span><b><span |
---|
852 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p></o:p></span></b></p> |
---|
853 | |
---|
854 | <p class=MsoNormal style='margin-left:35.4pt;mso-layout-grid-align:none; |
---|
855 | text-autospace:none'><b><span lang=EN-GB style='font-family:Arial;color:white; |
---|
856 | mso-ansi-language:EN-GB'><o:p> </o:p></span></b></p> |
---|
857 | |
---|
858 | <p class=MsoNormal style='margin-left:35.4pt;text-align:justify;text-justify: |
---|
859 | inter-ideograph;mso-layout-grid-align:none;text-autospace:none'><span |
---|
860 | class=GramE><span lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language: |
---|
861 | EN-GB'>►</span><span lang=EN-GB style='font-family:Arial;color:#CC99FF; |
---|
862 | mso-ansi-language:EN-GB'> <b>DEVELOPMENT OF A FOCUSED CHARGED PARTICLE |
---|
863 | MICROBEAM FOR THE IRRADIATION OF INDIVIDUAL CELLS.</b></span></span><b><span |
---|
864 | lang=EN-GB style='font-family:Arial;color:#CC99FF;mso-ansi-language:EN-GB'><o:p></o:p></span></b></p> |
---|
865 | |
---|
866 | <p class=MsoNormal style='margin-left:35.4pt;text-align:justify;text-justify: |
---|
867 | inter-ideograph;mso-layout-grid-align:none;text-autospace:none'><span |
---|
868 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>By Ph. |
---|
869 | <span class=SpellE>Barberet</span>, A. <span class=SpellE>Balana</span>, S. |
---|
870 | Incerti, C. <span class=SpellE>Michelet-Habchi</span>, Ph. Moretto, Th. <span |
---|
871 | class=SpellE>Pouthier</span>. Dec 2004. 6pp. <o:p></o:p></span></p> |
---|
872 | |
---|
873 | <p class=MsoNormal style='margin-left:35.4pt;text-align:justify;text-justify: |
---|
874 | inter-ideograph;mso-layout-grid-align:none;text-autospace:none'><span |
---|
875 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>Published |
---|
876 | in </span><b><span lang=EN-GB style='font-family:Arial;color:#FF9933; |
---|
877 | mso-ansi-language:EN-GB'>Rev.Sci.Instrum.76:015101, 2005<o:p></o:p></span></b></p> |
---|
878 | |
---|
879 | <p class=MsoNormal style='margin-left:35.4pt;text-align:justify;text-justify: |
---|
880 | inter-ideograph;mso-layout-grid-align:none;text-autospace:none'><span |
---|
881 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p> |
---|
882 | |
---|
883 | <p class=MsoNormal style='margin-left:35.4pt;text-align:justify;text-justify: |
---|
884 | inter-ideograph;mso-layout-grid-align:none;text-autospace:none'><span |
---|
885 | class=GramE><span lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language: |
---|
886 | EN-GB'>► </span><b><span lang=EN-GB style='font-family:Arial;color:#CC99FF; |
---|
887 | mso-ansi-language:EN-GB'>SIMULATION OF CELLULAR IRRADIATION WITH THE CENBG |
---|
888 | MICROBEAM LINE USING GEANT4.</span></b></span><b><span lang=EN-GB |
---|
889 | style='font-family:Arial;color:#CC99FF;mso-ansi-language:EN-GB'><o:p></o:p></span></b></p> |
---|
890 | |
---|
891 | <p class=MsoNormal style='margin-left:35.4pt;text-align:justify;text-justify: |
---|
892 | inter-ideograph;mso-layout-grid-align:none;text-autospace:none'><span |
---|
893 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>By S. |
---|
894 | Incerti, Ph. <span class=SpellE>Barberet</span>, R. <span class=SpellE>Villeneuve</span>, |
---|
895 | P. <span class=SpellE>Aguer</span>, E. <span class=SpellE>Gontier</span>, C. <span |
---|
896 | class=SpellE>Michelet-Habchi</span>, Ph. Moretto, D.T. Nguyen, T. <span |
---|
897 | class=SpellE>Pouthier</span>, R.W. Smith. Oct 2003. 6pp. <o:p></o:p></span></p> |
---|
898 | |
---|
899 | <p class=MsoNormal style='margin-left:35.4pt;text-align:justify;text-justify: |
---|
900 | inter-ideograph;mso-layout-grid-align:none;text-autospace:none'><span |
---|
901 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>Published |
---|
902 | in </span><b><span lang=EN-GB style='font-family:Arial;color:#FF9933; |
---|
903 | mso-ansi-language:EN-GB'>IEEE Trans.Nucl.Sci.51:1395-1401, 2004</span></b><span |
---|
904 | lang=EN-GB style='font-family:Arial;color:#FF9933;mso-ansi-language:EN-GB'><o:p></o:p></span></p> |
---|
905 | |
---|
906 | <p class=MsoNormal style='margin-left:35.4pt;text-align:justify;text-justify: |
---|
907 | inter-ideograph;mso-layout-grid-align:none;text-autospace:none'><span |
---|
908 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p> |
---|
909 | |
---|
910 | <p class=MsoNormal style='margin-left:35.4pt;mso-layout-grid-align:none; |
---|
911 | text-autospace:none'><span class=GramE><span lang=EN-GB style='font-family: |
---|
912 | Arial;color:white;mso-ansi-language:EN-GB'>►</span><span lang=EN-GB |
---|
913 | style='font-family:Arial;color:#CC99FF;mso-ansi-language:EN-GB'> <b>SIMULATION |
---|
914 | OF ION PROPAGATION IN THE MICROBEAM LINE OF CENBG USING GEANT4.</b></span></span><span |
---|
915 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><br> |
---|
916 | By </span><span style='font-family:Arial;color:white'><a |
---|
917 | href="http://www.slac.stanford.edu/spires/find/wwwhepau/wwwscan?rawcmd=fin+%22Incerti,+S.%22"><span |
---|
918 | lang=EN-GB style='color:white;mso-ansi-language:EN-GB;text-decoration:none; |
---|
919 | text-underline:none'>S. Incerti</span></a></span><span lang=EN-GB |
---|
920 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>, </span><span |
---|
921 | style='font-family:Arial;color:white'><a |
---|
922 | href="http://www.slac.stanford.edu/spires/find/wwwhepau/wwwscan?rawcmd=fin+%22Barberet,+Ph.%22"><span |
---|
923 | lang=EN-GB style='color:white;mso-ansi-language:EN-GB;text-decoration:none; |
---|
924 | text-underline:none'>Ph. <span class=SpellE>Barberet</span></span></a></span><span |
---|
925 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>, </span><span |
---|
926 | style='font-family:Arial;color:white'><a |
---|
927 | href="http://www.slac.stanford.edu/spires/find/wwwhepau/wwwscan?rawcmd=fin+%22Courtois,+B.%22"><span |
---|
928 | lang=EN-GB style='color:white;mso-ansi-language:EN-GB;text-decoration:none; |
---|
929 | text-underline:none'>B. <span class=SpellE>Courtois</span></span></a></span><span |
---|
930 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>, </span><span |
---|
931 | style='font-family:Arial;color:white'><a |
---|
932 | href="http://www.slac.stanford.edu/spires/find/wwwhepau/wwwscan?rawcmd=fin+%22Michelet-Habchi,+C.%22"><span |
---|
933 | lang=EN-GB style='color:white;mso-ansi-language:EN-GB;text-decoration:none; |
---|
934 | text-underline:none'>C. <span class=SpellE>Michelet-Habchi</span></span></a></span><span |
---|
935 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>, </span><span |
---|
936 | style='font-family:Arial;color:white'><a |
---|
937 | href="http://www.slac.stanford.edu/spires/find/wwwhepau/wwwscan?rawcmd=fin+%22Moretto,+Ph.%22"><span |
---|
938 | lang=EN-GB style='color:white;mso-ansi-language:EN-GB;text-decoration:none; |
---|
939 | text-underline:none'>Ph. <span class=SpellE>Moretto</span></span></a></span><span |
---|
940 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>. Sep |
---|
941 | 2003. <br> |
---|
942 | Published in </span><b><span lang=EN-GB style='font-family:Arial;color:#FF9933; |
---|
943 | mso-ansi-language:EN-GB'>Nucl.Instrum.Meth.B210:92-97, 2003</span></b><span |
---|
944 | lang=EN-GB style='font-family:Arial;color:#FFCCFF;mso-ansi-language:EN-GB'><o:p></o:p></span></p> |
---|
945 | |
---|
946 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
947 | mso-layout-grid-align:none;text-autospace:none'><b><span lang=EN-GB |
---|
948 | style='font-family:Arial;color:#66CCFF;mso-ansi-language:EN-GB'><o:p> </o:p></span></b></p> |
---|
949 | |
---|
950 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
951 | mso-layout-grid-align:none;text-autospace:none'><b><span lang=EN-GB |
---|
952 | style='font-family:Arial;color:#66CCFF;mso-ansi-language:EN-GB'><o:p> </o:p></span></b></p> |
---|
953 | |
---|
954 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
955 | mso-layout-grid-align:none;text-autospace:none'><b><span lang=EN-GB |
---|
956 | style='font-family:Arial;color:#66CCFF;mso-ansi-language:EN-GB'>HOW TO INSTALL |
---|
957 | AND RUN THE EXAMPLE<o:p></o:p></span></b></p> |
---|
958 | |
---|
959 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
960 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB |
---|
961 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p> |
---|
962 | |
---|
963 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
964 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB |
---|
965 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>Please, look at |
---|
966 | the </span><b><span lang=EN-GB style='font-family:Arial;color:yellow; |
---|
967 | mso-ansi-language:EN-GB'>README file</span></b><span lang=EN-GB |
---|
968 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'> provided with |
---|
969 | the example.<o:p></o:p></span></p> |
---|
970 | |
---|
971 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
972 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB |
---|
973 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p> |
---|
974 | |
---|
975 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
976 | mso-layout-grid-align:none;text-autospace:none'><b><span lang=EN-GB |
---|
977 | style='font-family:Arial;color:#66CCFF;mso-ansi-language:EN-GB'><o:p> </o:p></span></b></p> |
---|
978 | |
---|
979 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
980 | mso-layout-grid-align:none;text-autospace:none'><b><span lang=EN-GB |
---|
981 | style='font-family:Arial;color:#66CCFF;mso-ansi-language:EN-GB'>SIMULATION |
---|
982 | RESULTS<o:p></o:p></span></b></p> |
---|
983 | |
---|
984 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
985 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB |
---|
986 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p> |
---|
987 | |
---|
988 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
989 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB |
---|
990 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>This example does |
---|
991 | not need any external analysis tool. The output consists in several text |
---|
992 | (*.txt) files which are created directly in the <span class=SpellE>microbeam</span> |
---|
993 | <span class=GramE>directory :</span><o:p></o:p></span></p> |
---|
994 | |
---|
995 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
996 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB |
---|
997 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p> |
---|
998 | |
---|
999 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
1000 | text-indent:35.4pt;mso-layout-grid-align:none;text-autospace:none'><span |
---|
1001 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>► |
---|
1002 | </span><span class=GramE><b><span lang=EN-GB style='font-family:Arial; |
---|
1003 | color:#CC99FF;mso-ansi-language:EN-GB'>dose.txt</span></b><span lang=EN-GB |
---|
1004 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'> :</span></span><span |
---|
1005 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'> gives |
---|
1006 | the total deposited dose in the cell nucleus and in the cell cytoplasm for each |
---|
1007 | incident alpha particle;<o:p></o:p></span></p> |
---|
1008 | |
---|
1009 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
1010 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB |
---|
1011 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p> |
---|
1012 | |
---|
1013 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
1014 | text-indent:35.4pt;mso-layout-grid-align:none;text-autospace:none'><span |
---|
1015 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>► |
---|
1016 | </span><span class=GramE><b><span lang=EN-GB style='font-family:Arial; |
---|
1017 | color:#CC99FF;mso-ansi-language:EN-GB'>3DDose.txt</span></b><span lang=EN-GB |
---|
1018 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'> :</span></span><span |
---|
1019 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'> gives |
---|
1020 | the average dose deposited per <span class=SpellE>voxel</span> per incident |
---|
1021 | alpha particle;<o:p></o:p></span></p> |
---|
1022 | |
---|
1023 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
1024 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB |
---|
1025 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p> |
---|
1026 | |
---|
1027 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
1028 | text-indent:35.4pt;mso-layout-grid-align:none;text-autospace:none'><span |
---|
1029 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>► |
---|
1030 | </span><span class=GramE><b><span lang=EN-GB style='font-family:Arial; |
---|
1031 | color:#CC99FF;mso-ansi-language:EN-GB'>range.txt</span></b><span lang=EN-GB |
---|
1032 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'> :</span></span><span |
---|
1033 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'> |
---|
1034 | indicates the final stopping (<span class=SpellE>x,y,z</span>) position of the |
---|
1035 | incident alpha particle within the irradiated medium (cell or culture medium)<o:p></o:p></span></p> |
---|
1036 | |
---|
1037 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
1038 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB |
---|
1039 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p> |
---|
1040 | |
---|
1041 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
1042 | text-indent:35.4pt;mso-layout-grid-align:none;text-autospace:none'><span |
---|
1043 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>► |
---|
1044 | </span><span class=GramE><b><span lang=EN-GB style='font-family:Arial; |
---|
1045 | color:#CC99FF;mso-ansi-language:EN-GB'>stoppingPower.txt</span></b><span |
---|
1046 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'> :</span></span><span |
---|
1047 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'> gives |
---|
1048 | the actual stopping power <span class=SpellE>dE/dx</span> of the incident alpha |
---|
1049 | particle just before penetrating into the targeted cell;<o:p></o:p></span></p> |
---|
1050 | |
---|
1051 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
1052 | text-indent:35.4pt;mso-layout-grid-align:none;text-autospace:none'><span |
---|
1053 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p> |
---|
1054 | |
---|
1055 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
1056 | text-indent:35.4pt;mso-layout-grid-align:none;text-autospace:none'><span |
---|
1057 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>► |
---|
1058 | </span><span class=GramE><b><span lang=EN-GB style='font-family:Arial; |
---|
1059 | color:#CC99FF;mso-ansi-language:EN-GB'>beamPosition.txt</span></b><span |
---|
1060 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'> :</span></span><span |
---|
1061 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'> gives |
---|
1062 | the beam transverse position distribution (X and Y) just before penetrating |
---|
1063 | into the targeted cell;<o:p></o:p></span></p> |
---|
1064 | |
---|
1065 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
1066 | text-indent:35.4pt;mso-layout-grid-align:none;text-autospace:none'><span |
---|
1067 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p> |
---|
1068 | |
---|
1069 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
1070 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB |
---|
1071 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p> |
---|
1072 | |
---|
1073 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
1074 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB |
---|
1075 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>These files can |
---|
1076 | be easily analyzed using the provided </span><b><span lang=EN-GB |
---|
1077 | style='font-family:Arial;color:yellow;mso-ansi-language:EN-GB'>ROOT macro file</span></b><span |
---|
1078 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'> </span><span |
---|
1079 | class=SpellE><b><span lang=EN-GB style='font-family:Arial;color:yellow; |
---|
1080 | mso-ansi-language:EN-GB'>plot.C</span></b></span><span lang=EN-GB |
---|
1081 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>. Fore more |
---|
1082 | details, please refer to the </span><b><span lang=EN-GB style='font-family: |
---|
1083 | Arial;color:yellow;mso-ansi-language:EN-GB'>README file</span></b><span |
---|
1084 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>. The |
---|
1085 | ROOT website is available <span class=GramE>at :</span> </span><b><span |
---|
1086 | lang=EN-GB style='font-family:Arial;color:aqua;mso-ansi-language:EN-GB'><a |
---|
1087 | href="http://root.cern.ch/"><span style='color:aqua;text-decoration:none; |
---|
1088 | text-underline:none'>http://root.cern.ch</span></a></span></b><span lang=EN-GB |
---|
1089 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>. The macro gives |
---|
1090 | the following graphical <span class=GramE>output :</span><o:p></o:p></span></p> |
---|
1091 | |
---|
1092 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
1093 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB |
---|
1094 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p> |
---|
1095 | |
---|
1096 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
1097 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB |
---|
1098 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p> |
---|
1099 | |
---|
1100 | <p class=MsoNormal align=center style='text-align:center;mso-layout-grid-align: |
---|
1101 | none;text-autospace:none'><!--[if gte vml 1]><v:shape id="_x0000_i1032" type="#_x0000_t75" |
---|
1102 | style='width:691.5pt;height:506.25pt;mso-position-horizontal-relative:text; |
---|
1103 | mso-position-vertical-relative:text' o:allowoverlap="f"> |
---|
1104 | <v:imagedata src="microbeam_fichiers/image019.emz" o:title=""/> |
---|
1105 | </v:shape><![endif]--><![if !vml]><img border=0 width=922 height=675 |
---|
1106 | src="microbeam_fichiers/image013.gif" v:shapes="_x0000_i1032"><![endif]><span |
---|
1107 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p></o:p></span></p> |
---|
1108 | |
---|
1109 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm; |
---|
1110 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB |
---|
1111 | style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'><o:p> </o:p></span></p> |
---|
1112 | |
---|
1113 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm; |
---|
1114 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB |
---|
1115 | style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'>Typical |
---|
1116 | graphical output from the <span class=SpellE><b>plot.C</b></span> macro file |
---|
1117 | obtained for 2x10<sup>4</sup> incident alpha <span class=GramE>particles :</span><o:p></o:p></span></p> |
---|
1118 | |
---|
1119 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm; |
---|
1120 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB |
---|
1121 | style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'><o:p> </o:p></span></p> |
---|
1122 | |
---|
1123 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm; |
---|
1124 | mso-layout-grid-align:none;text-autospace:none'><b><span lang=EN-GB |
---|
1125 | style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'>TOP row <o:p></o:p></span></b></p> |
---|
1126 | |
---|
1127 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm; |
---|
1128 | mso-layout-grid-align:none;text-autospace:none'><span class=GramE><b><span |
---|
1129 | lang=EN-GB style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'>left</span></b></span><b><span |
---|
1130 | lang=EN-GB style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'> |
---|
1131 | plot :</span></b><span lang=EN-GB style='font-family:Arial;color:#CCFFCC; |
---|
1132 | mso-ansi-language:EN-GB'> <i>nucleus <span class=SpellE>voxel</span> intensity |
---|
1133 | (0-255) distribution, two density zones have been isolated in the simulation</i><o:p></o:p></span></p> |
---|
1134 | |
---|
1135 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm; |
---|
1136 | mso-layout-grid-align:none;text-autospace:none'><span class=GramE><b><span |
---|
1137 | lang=EN-GB style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'>middle</span></b></span><b><span |
---|
1138 | lang=EN-GB style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'> |
---|
1139 | left plot :</span></b><span lang=EN-GB style='font-family:Arial;color:#CCFFCC; |
---|
1140 | mso-ansi-language:EN-GB'> <i>alpha dose deposit in nucleus</i><o:p></o:p></span></p> |
---|
1141 | |
---|
1142 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm; |
---|
1143 | mso-layout-grid-align:none;text-autospace:none'><span class=GramE><b><span |
---|
1144 | lang=EN-GB style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'>middle</span></b></span><b><span |
---|
1145 | lang=EN-GB style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'> |
---|
1146 | right plot :</span></b><span lang=EN-GB style='font-family:Arial;color:#CCFFCC; |
---|
1147 | mso-ansi-language:EN-GB'> <i>nucleus <span class=SpellE>voxel</span> intensity |
---|
1148 | projected on cell transverse section<o:p></o:p></i></span></p> |
---|
1149 | |
---|
1150 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm; |
---|
1151 | mso-layout-grid-align:none;text-autospace:none'><span class=GramE><b><span |
---|
1152 | lang=EN-GB style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'>right</span></b></span><b><span |
---|
1153 | lang=EN-GB style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'> |
---|
1154 | plot :</span></b><i><span lang=EN-GB style='font-family:Arial;color:#CCFFCC; |
---|
1155 | mso-ansi-language:EN-GB'> beam transverse (X) position distribution on target. |
---|
1156 | The sigma of the Gaussian fit is compatible with the measured experimental |
---|
1157 | value.</span></i><span lang=EN-GB style='font-family:Arial;color:#CCFFCC; |
---|
1158 | mso-ansi-language:EN-GB'><o:p></o:p></span></p> |
---|
1159 | |
---|
1160 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm; |
---|
1161 | mso-layout-grid-align:none;text-autospace:none'><b><span lang=EN-GB |
---|
1162 | style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'><o:p> </o:p></span></b></p> |
---|
1163 | |
---|
1164 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm; |
---|
1165 | mso-layout-grid-align:none;text-autospace:none'><b><span lang=EN-GB |
---|
1166 | style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'>MIDDLE row <o:p></o:p></span></b></p> |
---|
1167 | |
---|
1168 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm; |
---|
1169 | mso-layout-grid-align:none;text-autospace:none'><span class=GramE><b><span |
---|
1170 | lang=EN-GB style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'>left</span></b></span><b><span |
---|
1171 | lang=EN-GB style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'> |
---|
1172 | plot :</span></b><span lang=EN-GB style='font-family:Arial;color:#CCFFCC; |
---|
1173 | mso-ansi-language:EN-GB'> <i>cytoplasm <span class=SpellE>voxel</span> |
---|
1174 | intensity (0-255) distribution, two density zones have been isolated (one for pure |
---|
1175 | cytoplasm in red, the other for nucleoli in yellow)</i><o:p></o:p></span></p> |
---|
1176 | |
---|
1177 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm; |
---|
1178 | mso-layout-grid-align:none;text-autospace:none'><span class=GramE><b><span |
---|
1179 | lang=EN-GB style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'>middle</span></b></span><b><span |
---|
1180 | lang=EN-GB style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'> |
---|
1181 | left plot :</span></b><span lang=EN-GB style='font-family:Arial;color:#CCFFCC; |
---|
1182 | mso-ansi-language:EN-GB'> <i>alpha dose deposit in cytoplasm<o:p></o:p></i></span></p> |
---|
1183 | |
---|
1184 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm; |
---|
1185 | mso-layout-grid-align:none;text-autospace:none'><span class=GramE><b><span |
---|
1186 | lang=EN-GB style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'>middle</span></b></span><b><span |
---|
1187 | lang=EN-GB style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'> |
---|
1188 | right plot :</span></b><span lang=EN-GB style='font-family:Arial;color:#CCFFCC; |
---|
1189 | mso-ansi-language:EN-GB'> <i>cytoplasm <span class=SpellE>voxel</span> |
---|
1190 | intensity projected on cell transverse section<o:p></o:p></i></span></p> |
---|
1191 | |
---|
1192 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm; |
---|
1193 | mso-layout-grid-align:none;text-autospace:none'><span class=GramE><b><span |
---|
1194 | lang=EN-GB style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'>right</span></b></span><b><span |
---|
1195 | lang=EN-GB style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'> |
---|
1196 | plot :</span></b><i><span lang=EN-GB style='font-family:Arial;color:#CCFFCC; |
---|
1197 | mso-ansi-language:EN-GB'> beam transverse (Y) position distribution on target. |
---|
1198 | The sigma of the Gaussian fit is compatible with the measured experimental |
---|
1199 | value.</span></i><span lang=EN-GB style='font-family:Arial;color:#CCFFCC; |
---|
1200 | mso-ansi-language:EN-GB'><o:p></o:p></span></p> |
---|
1201 | |
---|
1202 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm; |
---|
1203 | mso-layout-grid-align:none;text-autospace:none'><b><span lang=EN-GB |
---|
1204 | style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'><o:p> </o:p></span></b></p> |
---|
1205 | |
---|
1206 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm; |
---|
1207 | mso-layout-grid-align:none;text-autospace:none'><b><span lang=EN-GB |
---|
1208 | style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'>BOTTOM row <o:p></o:p></span></b></p> |
---|
1209 | |
---|
1210 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm; |
---|
1211 | mso-layout-grid-align:none;text-autospace:none'><span class=GramE><b><span |
---|
1212 | lang=EN-GB style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'>left</span></b></span><b><span |
---|
1213 | lang=EN-GB style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'> |
---|
1214 | plot :</span></b><span lang=EN-GB style='font-family:Arial;color:#CCFFCC; |
---|
1215 | mso-ansi-language:EN-GB'> <i>beam stopping power <span class=SpellE>dE/dx</span> |
---|
1216 | distribution at cell entrance<o:p></o:p></i></span></p> |
---|
1217 | |
---|
1218 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm; |
---|
1219 | mso-layout-grid-align:none;text-autospace:none'><span class=GramE><b><span |
---|
1220 | lang=EN-GB style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'>middle</span></b></span><b><span |
---|
1221 | lang=EN-GB style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'> |
---|
1222 | left plot :</span></b><span lang=EN-GB style='font-family:Arial;color:#CCFFCC; |
---|
1223 | mso-ansi-language:EN-GB'> <i>3D distribution of alpha particle range in cell or |
---|
1224 | medium<o:p></o:p></i></span></p> |
---|
1225 | |
---|
1226 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm; |
---|
1227 | mso-layout-grid-align:none;text-autospace:none'><span class=GramE><b><span |
---|
1228 | lang=EN-GB style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'>middle</span></b></span><b><span |
---|
1229 | lang=EN-GB style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'> |
---|
1230 | right plot :</span></b><span lang=EN-GB style='font-family:Arial;color:#CCFFCC; |
---|
1231 | mso-ansi-language:EN-GB'> <i>projected mean energy deposit per <span |
---|
1232 | class=SpellE>voxel</span> (transverse, z axis is in <span class=SpellE>eV</span>)<o:p></o:p></i></span></p> |
---|
1233 | |
---|
1234 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm; |
---|
1235 | mso-layout-grid-align:none;text-autospace:none'><span class=GramE><b><span |
---|
1236 | lang=EN-GB style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'>right</span></b></span><b><span |
---|
1237 | lang=EN-GB style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'> |
---|
1238 | plot : </span></b><i><span lang=EN-GB style='font-family:Arial;color:#CCFFCC; |
---|
1239 | mso-ansi-language:EN-GB'>projected mean energy deposit per <span class=SpellE>voxel</span> |
---|
1240 | (longitudinal, z axis is in <span class=SpellE>eV</span>).</span></i><span |
---|
1241 | lang=EN-GB style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'><o:p></o:p></span></p> |
---|
1242 | |
---|
1243 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm; |
---|
1244 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB |
---|
1245 | style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'><o:p> </o:p></span></p> |
---|
1246 | |
---|
1247 | <p class=MsoNormal align=center style='text-align:center;tab-stops:right 16.0cm; |
---|
1248 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB |
---|
1249 | style='font-family:Arial;color:#CCFFCC;mso-ansi-language:EN-GB'><o:p> </o:p></span></p> |
---|
1250 | |
---|
1251 | <p class=MsoNormal style='mso-layout-grid-align:none;text-autospace:none'><span |
---|
1252 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>The |
---|
1253 | simulation predicts that 95% of the incident alpha particles detected by the |
---|
1254 | gas detector are located within a circle of 10 µm in diameter on the target, in |
---|
1255 | nice agreement with experimental measurements performed on the CENBG setup.<o:p></o:p></span></p> |
---|
1256 | |
---|
1257 | <p class=MsoNormal align=center style='text-align:center;mso-layout-grid-align: |
---|
1258 | none;text-autospace:none'><span lang=EN-GB style='font-family:Arial;color:white; |
---|
1259 | mso-ansi-language:EN-GB'><o:p> </o:p></span></p> |
---|
1260 | |
---|
1261 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
1262 | mso-layout-grid-align:none;text-autospace:none'><b><span lang=EN-GB |
---|
1263 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></b></p> |
---|
1264 | |
---|
1265 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
1266 | mso-layout-grid-align:none;text-autospace:none'><b><span lang=EN-GB |
---|
1267 | style='font-family:Arial;color:#66CCFF;mso-ansi-language:EN-GB'>FUTURE<o:p></o:p></span></b></p> |
---|
1268 | |
---|
1269 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
1270 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB |
---|
1271 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p> |
---|
1272 | |
---|
1273 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
1274 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB |
---|
1275 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>Running this |
---|
1276 | example requires a large amount of memory and CPU time. Decrease of memory use |
---|
1277 | and acceleration of navigation could be investigated using nested |
---|
1278 | parameterization. Microdosimetry with other geometries like 3D tissues will be |
---|
1279 | investigated.<o:p></o:p></span></p> |
---|
1280 | |
---|
1281 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
1282 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB |
---|
1283 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p> |
---|
1284 | |
---|
1285 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
1286 | mso-layout-grid-align:none;text-autospace:none'><b><span lang=EN-GB |
---|
1287 | style='font-family:Arial;color:#66CCFF;mso-ansi-language:EN-GB'><o:p> </o:p></span></b></p> |
---|
1288 | |
---|
1289 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
1290 | mso-layout-grid-align:none;text-autospace:none'><b><span lang=EN-GB |
---|
1291 | style='font-family:Arial;color:#66CCFF;mso-ansi-language:EN-GB'>CONTACT<o:p></o:p></span></b></p> |
---|
1292 | |
---|
1293 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
1294 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB |
---|
1295 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p> |
---|
1296 | |
---|
1297 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
1298 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB |
---|
1299 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>Should you have |
---|
1300 | any enquiry, please do not hesitate to contact the corresponding <span |
---|
1301 | class=GramE>author :</span> </span><span lang=EN-GB style='font-family:Arial; |
---|
1302 | color:aqua;mso-ansi-language:EN-GB'><a href="mailto:incerti@cenbg.in2p3.fr"><span |
---|
1303 | style='color:aqua;text-decoration:none;text-underline:none'>incerti@cenbg.in2p3.fr</span></a> |
---|
1304 | <o:p></o:p></span></p> |
---|
1305 | |
---|
1306 | <p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph; |
---|
1307 | mso-layout-grid-align:none;text-autospace:none'><span lang=EN-GB |
---|
1308 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'><o:p> </o:p></span></p> |
---|
1309 | |
---|
1310 | <p class=MsoNormal align=right style='text-align:right;mso-layout-grid-align: |
---|
1311 | none;text-autospace:none'><span lang=EN-GB style='font-family:Arial;color:white; |
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1312 | mso-ansi-language:EN-GB'>Last modified by </span><st1:place><span lang=EN-GB |
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1313 | style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>S. Incerti</span></st1:place><span |
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1314 | lang=EN-GB style='font-family:Arial;color:white;mso-ansi-language:EN-GB'>, <span |
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1315 | style='mso-field-code:" DATE \\\@ \0022dd\/MM\/yyyy\0022 "'><span |
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1316 | style='mso-no-proof:yes'>27/02/2007</span></span><o:p></o:p></span></p> |
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1317 | |
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1318 | </div> |
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1319 | |
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1320 | </body> |
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1322 | </html> |
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