\subsection{Proton decay} Proton decay is one of the few predictions of Grand Unified Theories that can be tested in low-energy experiments. Its discovery would definitely testify for a more fundamental structure beyond the Standard Model. In the past twenty years, the first generation (IMB, Fr{\'e}jus, Kamiokande) and second generation (Super-Kamiokande) proton decay experiments have already put stringent lower limits on the partial proton lifetimes, qualitatively ruling out non-supersymmetric $SU(5)$ theories (first generation) and the minimal supersymmetric $SU(5)$ theory (second generation). A megaton-scale water \v{C}erenkov detector would improve further the experimental sensitivity to proton decay by more than one order of magnitude and allow to probe non-minimal $SU(5)$ models as well as other types of GUTs, such as $SO(10)$, flipped $SU(5)$ and higher-dimensional GUTs. Indeed, recent experimental and theoretical progresses point towards smaller values of the partial lifetime of the proton into $\pi^0 e^+$, implying that this decay mode -- the most model-independent one -- is not out of reach, contrary to previous expectations. Using the new, more accurate lattice calculation of the nucleon decay matrix element one can estimate $\tau (p \rightarrow \pi^0 e^+) \approx 10^{35}\, \mbox{yrs}\, (M_X / 10^{16}\, \mbox{GeV})^4\, ((1/25) / \alpha_{GUT})^2$, where $M_X$ is the mass of the superheavy gauge bosons mediating proton decay, $\alpha_{GUT} \equiv g^2_{GUT} / 4 \pi$ and $g_{GUT}$ is the value of the GUT gauge coupling at the unification scale. This is to be compared with the present Super-Kamiokande lower limit ($5 \times 10^{33}\, \mbox{yrs}$), and with the expected sensivity of a megaton water \v{C}erenkov detector ($10^{35}\, \mbox{yrs}$ after 10 years of data taking for MEMPHYS). The dominant decay channel in supersymmetric GUTs, $p \rightarrow K^+ \bar \nu$, is much more model-dependent. The corresponding decay rate indeed depends on the couplings and masses of the supersymmetric partners of the heavy colour-triplet Higgs bosons, and on the details of the sparticle spectrum. The effective triplet mass, in particular, is extremely dependent on the GUT model. %In the %simplest models, $\tau (p \rightarrow K^+ \bar \nu)$ strongly depends on %$\tan \beta$, the ratio of the vevs of the two Higgs bosons of the MSSM; %larger values of $\tan \beta$ yield shorter values of %$\tau (p \rightarrow K^+ \bar \nu)$. In many models, one finds an upper limit $\tau (p \rightarrow K^+ \bar \nu) \leq \mbox{few}\, 10^{34}\, \mbox{yrs}$ \cite{Dermisek:2000hr}\cite{Babu:1998wi}\cite{Altarelli:2000fu}, to be compared with the present Super-Kamioka nde lower limit ($1.6 \times 10^{33}\, \mbox{yrs}$), and with the expected sensivity of a megaton water \v{C}erenkov detector ($2 \times 10^{34}\, \mbox{yrs}$ after 10 years for MEMPHYS). There are many more decay channels that could be accessible to a megaton water \v{C}erenkov detector. The measurement of several partial lifetimes would allow to discriminate between different Grand Unified models, at a time when, after several years of LHC running, the supersymmetry landscape will be drastically clarified, through discovery or severe exclusion limits. Therefore the predictions of proton lifetime, in constrained or more general supersymmetric models, will be sharpened even further.